One-Pot Synthesis of Thieno[2,3-b]pyridine and Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine Derivatives

被引：10
|
作者：
Dyachenko, I. V. [1 ]
Dyachenko, V. D. [1 ]
Dorovatovsky, P. V. [2 ]
Khrustalev, V. N. [3 ,4 ]
Nenajdenko, V. G. [5 ]
机构：
[1] Taras Shevchenko Lugansk Natl Univ, UA-91011 Lugansk, Ukraine
[2] Kurchatov Inst, Natl Res Ctr, Moscow 123182, Russia
[3] Peoples Friendship Univ Russia, Moscow 117198, Russia
[4] Russian Acad Sci, Zelinsky Inst Organ Chem, Moscow 119991, Russia
[5] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119991, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 06期
关键词：
3-methyl(ethyl)pentane-2,4-diones; cyanothioacetamide; alpha-halocarbonyl compounds; cyclohexanone; formamide; thieno[2,3-b]pyridines; pyrido[3 ',2 ':4,5]thieno[3,2-d]pyrimidines; X-ray analysis;
D O I：
10.1134/S1070428020060020
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Acyl-4,5,6-trialkyl-3-aminothieno[2,3-b]pyridines, 8 '-ethyl-7 ',9 '-dimethyl-1 ' H-spiro[cyclohexane-1,2 '-pyrido[3 ',2 ':4,5]thieno[3,2-d]pyrimidin]-4 '(3 ' H)-one, and 7,8,9-trimethylpyrido[3 ',2 ':4,5]thieno[3,2-d]pyrimidin-4-amine have been synthesized by one-pot three-component condensation of 3-methyl(ethyl)pentane-2,4-diones with cyanothioacetamide and alpha-halocarbonyl compounds, cyclohexanone, or formamide. The structures of some of the synthesized thieno[2,3-b]pyridine derivatives have been studied by X-ray analysis.
引用
收藏
页码：974 / 982
页数：9
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