Synthesis and Antinociceptive Activity of Substituted 5-(Het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones

被引：20
|
作者：
Lipin, D. V. [1 ]
Denisova, E. I. [1 ,2 ]
Devyatkin, I. O. [2 ]
Okoneshnikova, E. A. [1 ]
Shipilovskikh, D. A. [1 ,3 ]
Makhmudov, R. R. [1 ,4 ]
Igidov, N. M. [2 ]
Shipilovskikh, S. A. [1 ,5 ]
机构：
[1] Perm State Univ, Perm 614990, Russia
[2] Perm State Pharmaceut Acad, Perm 614990, Russia
[3] Perm Natl Res Polytech Univ, Perm 614990, Russia
[4] Fed Res Ctr Med & Prevent Technol Managing Publ H, Perm 614045, Russia
[5] ITMO Univ, Sch Phys & Engn, St Petersburg 197101, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 12期
关键词：
2; 4-dioxobutanoic acids; 3-imino(hydrazono)furan-2(3H)-one; antinociceptive activity; CAP-SNATCHING ENDONUCLEASE; DIKETO ACIDS;
D O I：
10.1134/S1070363221120161
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The method was proposed for the synthesis of new substituted 5-(het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones by intramolecular cyclization of 2-[2-(4-methylbenzoyl)hydrazono]-4-oxobut-2-enoic acids in the presence of propionic anhydride. The antinociceptive activity of the obtained compounds was studied.
引用
收藏
页码：2469 / 2474
页数：6
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