Logic functions of the genomic cis-regulatory code

被引:127
|
作者
Istrail, S
Davidson, EH [1 ]
机构
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
[2] Appl Biosyst Celera Genom, Rockville, MD 20850 USA
关键词
D O I
10.1073/pnas.0409624102
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
cis-regulatory modules that control developmental gene expression process the regulatory inputs provided by the transcription factors for which they contain specific target sites. A prominent class of cis-regulatory processing functions can be modeled as logic operations. Many of these are combinatorial because they are mediated by multiple sites, although others are unitary. In this work, we illustrate the repertoire of cis-regulatory logic operations, as an approach toward a functional interpretation of the genomic regulatory code.
引用
收藏
页码:4954 / 4959
页数:6
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