Data-Driven Approaches to Executive Function Performance and Structure in Aging: Integrating Person-Centered Analyses and Machine Learning Risk Prediction

被引:2
|
作者
Caballero, H. Sebastian [1 ]
McFall, G. Peggy [1 ,2 ]
Zheng, Yao [2 ]
Dixon, Roger A. [1 ,2 ]
机构
[1] Univ Alberta, Neurosci & Mental Hlth Inst, Edmonton, AB, Canada
[2] Univ Alberta, Dept Psychol, P-217 Biol Sci Bldg, Edmonton, AB T6G 2E9, Canada
基金
美国国家卫生研究院; 加拿大健康研究院;
关键词
executive function; risk factor predictors; data-driven analyses; Victoria Longitudinal Study; BODY-MASS INDEX; CATECHOL-O-METHYLTRANSFERASE; OLDER-ADULTS; INDIVIDUAL-DIFFERENCES; COGNITIVE RESERVE; PHYSICAL-ACTIVITY; SEX-DIFFERENCES; PULSE PRESSURE; RANDOM FOREST; LATE-LIFE;
D O I
10.1037/neu0000775
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Objective: Executive function (EF) performance and structure in nondemented aging are frequently examined with variable-centered approaches. Person-centered analytics can contribute unique information about classes of persons by simultaneously considering EF performance and structure. The risk predictors of these classes can then be determined by machine learning technology. Using data from the Victoria Longitudinal Study we examined two goals: (a) detect different underlying subgroups (or classes) of EF performance and structure and (b) test multiple risk predictors for best discrimination of these detected subgroups. Method: We used a classification sample (n = 778; Mage = 71.42) for the first goal and a prediction subsample (n = 570; Mage = 70.10) for the second goal. Eight neuropsychological measures represented three EF dimensions (inhibition, updating, shifting). Fifteen predictors represented five domains (genetic, functional, lifestyle, mobility, demographic). Results: First, we observed two distinct classes: (a) lower EF performance and unidimensional structure (Class 1) and (b) higher EF performance and multidimensional structure (Class 2). Second, Class 2 was predicted by younger age, more novel cognitive activity, more education, lower body mass index, lower pulse pressure, female sex, faster balance, and more physical activity. Conclusions: Data-driven modeling approaches tested the possibility of an EF aging class that displayed both preserved EF performance levels and sustained multidimensional structure. The two observed classes differed in both performance level (lower, higher) and structure (unidimensional, multidimensional). Machine learning prediction analyses showed that the higher performing and multidimensional class was associated with multiple brain health-related protective factors.
引用
收藏
页码:889 / 903
页数:15
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