Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks of Walsura robusta

被引：19
|
作者：
An, Fa-Liang
Sun, Dong-Mei
Li, Rui-Jun
Zhou, Miao-Miao
Yang, Ming-Hua
Yin, Yong
Kong, Ling-Yi [1 ]
Luo, Jun [1 ]
机构：
[1] China Pharmaceut Univ, Jiangsu Key Lab Bioact Nat Prod Res, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 17期
基金：
中国国家自然科学基金;
关键词：
INSECT ANTIFEEDANTS;
D O I：
10.1021/acs.orglett.7b02173
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Walrobsins A (1) and B (2), two limonoids featuring an unprecedented 5-oxatricyclo[5.4.1(1,4)]hendecane ring system, were isolated from the root barks of Walsura robusta. Their structures, including their absolute configurations, were determined by analyses of HR-ESIMS, 1D/2D NMR, and X-ray crystallography. Compounds 1 and 2 possessed a stable hemiketal structure formed between the OH-11 and 3-carbonyl group in the hexatomic oxoheterocyclic ring. Compound 1 showed significant anti-inflammatory activity with an IC50 value of 7.8 mu M and inhibited the expression of iNOS and IL-1 beta in a dose-dependent manner.
引用
收藏
页码：4568 / 4571
页数：4
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