The role of exosomes in metastasis and progression of melanoma

被引：64

作者：

Gowda, Raghavendra ^{[1
,5
,6
,7
]}

Robertson, Bailey M. ^{[1
]}

Iyer, Soumya ^{[1
,5
]}

Barry, John ^{[1
]}

Dinavahi, Saketh S. ^{[1
,5
]}

Robertson, Gavin P. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Penn State Univ, Coll Med, Dept Pharmacol, 500 Univ Dr, Hershey, PA 17033 USA

[2] Penn State Univ, Dept Pathol, Coll Med, Hershey, PA 17033 USA

[3] Penn State Univ, Dept Dermatol, Coll Med, Hershey, PA 17033 USA

[4] Penn State Univ, Dept Surg, Coll Med, Hershey, PA 17033 USA

[5] Penn State Univ, Penn State Melanoma & Skin Canc Ctr, Coll Med, Hershey, PA 17033 USA

[6] Penn State Univ, Penn State Melanoma Therapeut Program, Coll Med, Hershey, PA 17033 USA

[7] Penn State Univ, Foreman Fdn Melanoma Res, Coll Med, Hershey, PA 17033 USA

来源：

CANCER TREATMENT REVIEWS | 2020年 / 85卷

关键词：

Exosome; Multivesicular bodies; Melanoma; Metastasis; Angiogenesis; Drug delivery; CELL-DERIVED EXOSOMES; CANCER-ASSOCIATED FIBROBLASTS; DRUG-DELIVERY VEHICLES; BREAST-CANCER; EXTRACELLULAR VESICLES; DIAGNOSTIC BIOMARKERS; TUMOR PROGRESSION; MICRORNA; EXPRESSION; SECRETION;

D O I：

10.1016/j.ctrv.2020.101975

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanisms of melanoma metastasis have been the subject of extensive research for decades. Improved diagnostic and therapeutic strategies are of increasing importance for the treatment of melanoma due to its high burden of mortality in the advanced stages of the disease. Intercellular communication is a critical event for the progression of cancer. Collective evidence suggests that exosomes, small extracellular membrane vesicles released by the cells, are important facilitators of intercellular communication between the cells and the surrounding environment. Although the emerging field of exosomes is rapidly gaining traction in the scientific community, there is limited knowledge regarding the role of exosomes in melanoma. This review discusses the multifaceted role of melanoma-derived exosomes in promoting the process of metastasis by modulating the invasive and angiogenic capacity of malignant cells. The future implications of exosome research and the therapeutic potential of exosomes are also discussed.

引用

页数：11

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