Prospects of stem cell therapy in osteoarthritis

被引：1

作者：

Roberts, Sally ^{[1
]}

Genever, Paul ^{[1
,2
]}

McCaskie, Andrew ^{[1
,3
,4
]}

De Bari, Cosimo ^{[1
,5
]}

机构：

[1] Arthritis Res UK Tissue Engn Ctr, Kobe, Hyogo, Japan

[2] Univ York, Dept Biol, York YO10 5DD, N Yorkshire, England

[3] Newcastle Univ, Musculoskeletal Res Grp, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[5] Univ Aberdeen, Musculoskeletal Programme, Sch Med & Dent, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

REGENERATIVE MEDICINE | 2011年 / 6卷 / 03期

基金：

英国医学研究理事会;

关键词：

articular cartilage; bone; immunomodulatory; mesenchymal stem cell; stem cell niches; HUMAN BONE-MARROW; SPONTANEOUS MALIGNANT-TRANSFORMATION; CHONDROGENIC PROGENITOR CELLS; SYMPTOMATIC CARTILAGE DEFECTS; MESENCHYMAL STROMAL CELLS; IN-VITRO; IMMUNOMODULATORY PROPERTIES; INTERNATIONAL-SOCIETY; CROSS-CONTAMINATION; TELOMERASE ACTIVITY;

D O I：

10.2217/RME.11.21

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Osteoarthritis is a common disorder in which there is not only extensive degeneration but also an aberrant attempt at repair in joints. Stem cell therapy could provide a permanent, biological solution, with all sources of stem cells (embryonic, fetal and adult) showing some degree of potential. Mesenchymal stromal/stem cells, however, appear to be the leading candidates because of their ability to be sourced from many or all joint tissues. They may also modulate the immune response of individuals, in a manner influenced by local factors. This biological behavior of stem cells renders the application of regulatory standardizations challenging in comparison to pharmaceutical therapies. However, this would not be an issue if endogenous stem cells were activated to effect repair of an arthritic joint.

引用

页码：351 / 366

页数：16

共 50 条

[31] Embryonic stem cells, their pretenders, and prospects for cell therapy
Colman, Alan
XENOTRANSPLANTATION, 2007, 14 (05) : 442 - 442
[32] Mesenchymal Stem Cell Insights: Prospects in Cardiovascular Therapy
Chou, Shiu-Huey
Lin, Shinn-Zong
Kuo, Wei-Wen
Pai, Peiying
Ling, Jing-Ying
Lai, Chao-Hung
Kuo, Chia-Hua
Lin, Kuan-Ho
Tsai, Fuu-Jen
Huang, Chih-Yang
CELL TRANSPLANTATION, 2014, 23 (4-5) : 513 - 529
[33] Progress and prospects in stem cell therapy and drug discovery
Zhou, Qi
ACTA PHARMACOLOGICA SINICA, 2013, 34 (06) : 717 - 718
[34] Cell-free therapy for canine osteoarthritis: current evidence and prospects
Sharun, Khan
Muthu, Sathish
Mankuzhy, Pratheesh D.
Pawde, Abhijit M.
Chandra, Vikash
Lorenzo, Jose M.
Dhama, Kuldeep
Amarpal, G. Taru
Sharma, G. Taru
VETERINARY QUARTERLY, 2022, 42 (01) : 224 - 230
[35] Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role of the Cell Secretome
Mancuso, Patrizio
Raman, Swarna
Glynn, Aoife
Barry, Frank
Murphy, J. Mary
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2019, 7 (JAN)
[36] Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis
Burke, John
Hunter, Monte
Kolhe, Ravindra
Isales, Carlos
Hamrick, Mark
Fulzele, Sadanand
CLINICAL AND TRANSLATIONAL MEDICINE, 2016, 5
[37] Mesenchymal stem cell therapy for hip osteoarthritis : a systematic review
Biazzo, Alessio
Masia, Francesco
Verde, Francesco
ACTA ORTHOPAEDICA BELGICA, 2021, 87 (ES1): : 1 - 7
[38] STEM CELL THERAPY FOR KNEE OSTEOARTHRITIS- A COMPREHENSIVE REVIEW
Qayum, H. Abdul
Tariq, Amanuliah
Awais, M.
Raheem, Abdul
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 6 (06): : 13091 - 13096
[39] Embryonic stem cells: Prospects for developmental biology and cell therapy
Wobus, AM
Boheler, KR
PHYSIOLOGICAL REVIEWS, 2005, 85 (02) : 635 - 678
[40] Rationale and prospects of mesenchymal stem cell therapy for liver transplantation
Obermajer, Natasa
Popp, Felix C.
Johnson, Christian L.
Benseler, Volker
Dahlke, Marc H.
CURRENT OPINION IN ORGAN TRANSPLANTATION, 2014, 19 (01) : 60 - 64

← 1 2 3 4 5 →