Soluble chemokine receptor CXCR4 is present in human sera

被引：9
|
作者：
Malvoisin, Etienne [1 ]
Livrozet, Jean-Michel [1 ]
Makloufi, Djamila [1 ]
Vincent, Nadine [2 ]
机构：
[1] CHU Lyon, Hop Edouard Herriot, Dept Transplantat & Immunol Clin, F-69437 Lyon, France
[2] Fac Med, Grp Immunite Muqueuses & Agents Pathogenes, F-42023 St Etienne, France
来源：
ANALYTICAL BIOCHEMISTRY | 2011年 / 414卷 / 02期
关键词：
CXCR4; Isoelectric focusing; HIV-1; HEPATOCELLULAR-CARCINOMA; LIVER; EXPRESSION; CANCER; INFLAMMATION; ANTAGONIST; AXIS; IDENTIFICATION; METASTASIS; BLOCKADE;
D O I：
10.1016/j.ab.2011.03.022
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A soluble form of the chemokine receptor CXCR4 was detected in human sera by isoelectric focusing and Western blotting. Sera of patients and normal subjects were analyzed using a panel of specific antibodies. Compared with controls, high levels of serum CXCR4 were found in patients with inflammatory bowel diseases. Serum CXCR4 levels in the majority of HIV patients were similar to those in healthy controls. A sensitive polyclonal antibody was developed in rabbit immunized with a maltose binding protein (MBP) construct expressing the full-length CXCR4. Using anti-MBPCXCR4 antibody, the level of CXCR4 in sera of a majority of patients with fibrosis was very low. The potential of serum CXCR4 as a new diagnostic biomarker warrants further investigation. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：202 / 207
页数：6
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