Synthesis of polysubstituted imidazo[1,2-a]pyridines via microwave-assisted one-pot cyclization/Suzuki Coupling/Palladium-Catalyzed heteroarylation

被引：95
|
作者：
Koubachi, Jarnal
El Kazzouli, Said
Berteina-Raboin, Sabine
Mouaddib, Abderrahim
Guillaumet, Gerald
机构：
[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt, F-45067 Orleans 2, France
[2] Univ Cadi Ayyad, Fac Sci & Tech Beni Mellal, Beni Mellal 23000, Morocco
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 20期
关键词：
D O I：
10.1021/jo0712603
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A new and efficient method for the synthesis of 2,3,6-trisubstituted imidazo[1,2-a]pyridine derivatives using a microwave-assisted one-pot, two-step Suzuki/heteroarylation or one-pot, three-step cyclization/Suzuki/heteroarylation was developed. Polysubstituted compounds are obtained in good yield from 2-amino-5-halogenopyridines, 2-halogenocarbonyl derivatives, boronic acids, and heteroaryl bromides.
引用
收藏
页码：7650 / 7655
页数：6
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