Circadian oscillators in eukaryotes

被引：24

作者：

Jolma, Ingunn W. ^{[1
]}

Laerum, Ole Didrik ^{[2
]}

Lillo, Cathrine ^{[1
]}

Ruoff, Peter ^{[1
]}

机构：

[1] Univ Stavanger, Fac Sci & Technol, Ctr Organelle Res, Stavanger, Norway

[2] Haukeland Hosp, Dept Pathol, Gade Inst, N-5021 Bergen, Norway

来源：

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2010年 / 2卷 / 05期

关键词：

HUMAN BONE-MARROW; INTERLOCKED FEEDBACK LOOPS; LIGHT SIGNAL-TRANSDUCTION; CLOCK GENE-EXPRESSION; TEMPERATURE-COMPENSATION; NEUROSPORA-CRASSA; WHITE COLLAR-1; PERIOD LENGTH; DEPENDENT PHOSPHORYLATION; FREQUENCY DETERMINES;

D O I：

10.1002/wsbm.81

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The biological clock, present in nearly all eukaryotes, has evolved such that organisms can adapt to our planet's rotation in order to anticipate the coming day or night as well as unfavorable seasons. As all modern high-precision chronometers, the biological clock uses oscillation as a timekeeping element. In this review, we describe briefly the discovery, historical development, and general properties of circadian oscillators. The issue of temperature compensation (TC) is discussed, and our present understanding of the underlying genetic and biochemical mechanisms in circadian oscillators are described with special emphasis on Neurospora crassa, mammals, and plants. (C) 2010 John Wiley & Sons, Inc. WIREs Syst Biol Med 2010 2 533-549

引用

页码：533 / 549

页数：17

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