Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans

被引：2

作者：

Sarfo, Fred S. ^{[1
]}

Ovbiagele, Bruce ^{[2
]}

Gebregziabher, Mulugeta ^{[3
]}

Akpa, Onoja ^{[4
]}

Akpalu, Albert ^{[5
]}

Wahab, Kolawole ^{[6
]}

Ogbole, Godwin ^{[4
]}

Akinyemi, Rufus ^{[7
]}

Obiako, Reginald ^{[8
]}

Komolafe, Morenikeji ^{[9
]}

Owolabi, Lukman ^{[10
]}

Lackland, Daniel ^{[3
]}

Arnett, Donna ^{[11
]}

Tiwari, Hemant ^{[12
]}

Markus, Hugh S. ^{[13
]}

Akinyemi, Joshua ^{[4
]}

Oguntade, Ayodipupo ^{[4
]}

Fawale, Bimbo ^{[9
]}

Adeoye, Abiodun ^{[4
]}

Olugbo, Obiabo ^{[14
]}

Ogunjimi, Luqman ^{[4
]}

Osaigbovo, Godwin ^{[15
]}

Jenkins, Carolyn ^{[3
]}

Chukwuonye, Ijezie ^{[16
]}

Ajose, Olabamiji ^{[9
]}

Oyinloye, Lekan ^{[6
]}

Mutiso, Fedelis ^{[3
]}

Laryea, Ruth ^{[5
]}

Calys-Tagoe, Benedict ^{[5
]}

Salaam, Abdul ^{[15
]}

Amusa, Ganiyu ^{[15
]}

Olowookere, Samuel ^{[9
]}

Imoh, Chidiebere ^{[15
]}

Mande, Aliyu ^{[10
]}

Arulogun, Oyedunni ^{[4
]}

Adekunle, Fakunle ^{[4
]}

Appiah, Lambert ^{[1
]}

Balogun, Olayemi ^{[8
]}

Singh, Arti ^{[1
]}

Adeleye, Osi ^{[7
]}

Ogah, Okechukwu ^{[4
]}

Makanjuola, Akintomiwa ^{[4
]}

Owusu, Dorcas ^{[1
]}

Kolo, Philip ^{[6
]}

Adebayo, Oladimeji ^{[4
]}

Agunloye, Atinuke ^{[4
]}

Shidali, Vincent ^{[8
]}

Faniyan, Moyinoluwalogo ^{[4
]}

Lakoh, Sulaiman ^{[4
]}

Diala, Samuel ^{[4
]}

机构：

[1] Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana

[2] Univ Calif San Francisco, San Francisco, CA 94143 USA

[3] Med Univ South Carolina, Charleston, SC 29425 USA

[4] Univ Ibadan, Coll Med, Ibadan, Nigeria

[5] Univ Ghana, Sch Med, Accra, Ghana

[6] Univ Ilorin, Teaching Hosp, Ilorin, Nigeria

[7] Fed Med Ctr, Abeokuta, Nigeria

[8] Ahmadu Bello Univ, Zaria, Nigeria

[9] Obafemi Awolowo Univ, Teaching Hosp, Ife, Nigeria

[10] Aminu Kano Teaching Hosp, Kano, Nigeria

[11] Univ Kentucky, Lexington, KY 40506 USA

[12] Univ Alabama Birmingham, Birmingham, AL USA

[13] Univ Cambridge, Cambridge, England

[14] Delta State Univ, Teaching Hosp, Cleveland, MS USA

[15] Jos Teaching Hosp, Jos, Plateau State, Nigeria

[16] Fed Med Ctr, Umuahia, Abia State, Nigeria

[17] Fed Med Ctr, Owo, Ondo State, Nigeria

[18] Ladoke Akintola Univ Technol, Teaching Hosp, Ogbomosho, Oyo State, Nigeria

来源：

NEUROLOGY | 2020年 / 94卷 / 10期

关键词：

STROKE INCIDENCE; BLOOD-PRESSURE; GLOBAL BURDEN; MORTALITY; CLASSIFICATION; EPIDEMIOLOGY; INTERSTROKE; PREDICTORS; COUNTRIES; PATTERNS;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective To characterize risk factors for spontaneous intracerebral hemorrhage (sICH) occurrence and severity among West Africans. Methods The Stroke Investigative Research and Educational Network (SIREN) study is a multicenter case-control study involving 15 sites in Ghana and Nigeria. Patients were adults >= 18 years old with CT-confirmed sICH with age-, sex-, and ethnicity-matched stroke-free community controls. Standard instruments were used to assess vascular, lifestyle, and psychosocial factors. Factors associated with sICH and its severity were assessed using conditional logistic regression to estimate odds ratios (ORs) and population-attributable risks (PARs) with 95% confidence intervals (CIs) for factors. Results Of 2,944 adjudicated stroke cases, 854 were intracerebral hemorrhage (ICH). Mean age of patients with ICH was 54.7 +/- 13.9 years, with a male preponderance (63.1%), and 77.3% were nonlobar. Etiologic subtypes of sICH included hypertension (80.9%), structural vascular anomalies (4.0%), cerebral amyloid angiopathy (0.7%), systemic illnesses (0.5%), medication-related (0.4%), and undetermined (13.7%). Eight factors independently associated with sICH occurrence by decreasing order of PAR with their adjusted OR (95% CI) were hypertension, 66.63 (20.78-213.72); dyslipidemia, 2.95 (1.84-4.74); meat consumption, 1.55 (1.01-2.38); family history of CVD, 2.22 (1.41-3.50); nonconsumption of green vegetables, 3.61 (2.07-6.31); diabetes mellitus, 2.11 (1.29-3.46); stress, 1.68 (1.03-2.77); and current tobacco use, 14.27 (2.09-97.47). Factors associated with severe sICH using an NIH Stroke Scale score >15 with adjusted OR (95% CI) were nonconsumption of leafy green vegetables, 2.03 (1.43-2.88); systolic blood pressure for each mm Hg rise, 1.01 (1.00-1.01); presence of midline shift, 1.54 (1.11-2.13); lobar ICH, 1.72 (1.16-2.55); and supratentorial bleeds, 2.17 (1.06-4.46). Conclusions Population-level control of the dominant factors will substantially mitigate the burden of sICH in West Africa.

引用

页码：E998 / E1012

页数：15

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