Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression

被引：82
|
作者：
Dejonckheere, Eline [1 ,2 ]
Vandenbroucke, Roosmarijn E. [1 ,2 ]
Libert, Claude [1 ,2 ]
机构：
[1] VIB, DBMR, Dept Mol Biomed Res, B-9052 Ghent, Zwijnaarde, Belgium
[2] Univ Ghent, Dept Mol Biol, B-9000 Ghent, Belgium
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 02期
关键词：
MMP8; Inflammation; Cancer; GINGIVAL CREVICULAR FLUID; COLLAGENASE-2; MMP-8; EXPRESSION; IN-VIVO; TISSUE INHIBITOR; NEUTROPHIL COLLAGENASE; CHRONIC PERIODONTITIS; ADULT PERIODONTITIS; INDUCED SPUTUM; PLASMA-LEVELS; UP-REGULATION;
D O I：
10.1016/j.cytogfr.2011.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover, modulation of inflammatory responses and other physiological processes is well documented. Several recent studies highlight the involvement of MMP8 in a wide range of pathologies. This review will shed light on the putative role of MMP8 as a drug target or disease marker in some inflammatory disorders and in cancer progression. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：73 / 81
页数：9
相关论文
共 50 条
  • [21] The role of inflammatory mediators in cancer progression
    Nakada, M
    Song, XY
    Trikha, M
    Yan, L
    [J]. JOURNAL OF IMMUNOTHERAPY, 2003, 26 (06): : S27 - S27
  • [22] THE ROLE OF THE MATRIX METALLOPROTEINASE STROMELYSIN IN THE PROGRESSION OF SQUAMOUS-CELL CARCINOMAS
    MATRISIAN, LM
    MCDONNELL, S
    MILLER, DB
    NAVRE, M
    SEFTOR, EA
    HENDRIX, MJC
    [J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1991, 302 (03): : 157 - 162
  • [23] EFFECT OF MATRIX METALLOPROTEINASE-8 DEFICIENCY ON LIVER FIBROSIS PROGRESSION AND REGRESSION
    Kim, Y. O.
    Stoll, M.
    Weng, S. -Y.
    Hebich, B.
    Resa, T.
    Heck, R.
    Park, K. -S.
    Biwer, U.
    Schuppan, D.
    [J]. JOURNAL OF HEPATOLOGY, 2013, 58 : S457 - S457
  • [24] Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states
    Pagenstecher, A
    Stalder, AK
    Kincaid, CL
    Shapiro, SD
    Campbell, IL
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 1998, 152 (03): : 729 - 741
  • [25] Role of serum matrix metalloproteinase in the diagnosis of gastric cancer
    Liu, Jian
    Zhou, Liya
    Lin, Sanren
    Yao, Bei
    [J]. PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2020, 36 (05) : 1025 - 1031
  • [26] The paradoxical role of matrix metalloproteinase-11 in cancer
    Ma, Bing
    Ran, Rui
    Liao, Hai-Yang
    Zhang, Hai-Hong
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2021, 141
  • [27] Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis
    Li, Shun
    Pritchard, David Mark
    Yu, Lu-Gang
    [J]. CANCERS, 2022, 14 (13)
  • [28] The matrix-metalloproteinase inhibitor RECK affects prostate cancer progression
    Rabien, A.
    Ergun, B.
    Lein, M.
    Stephan, C.
    Jung, K.
    [J]. EUROPEAN UROLOGY SUPPLEMENTS, 2008, 7 (03) : 175 - 175
  • [29] The role of interleukin-8 (IL-8), matrix metalloproteinase-2 and-9 (MMP-2 and MMP-9) in breast cancer progression
    Milovanovic, J.
    Todorovic-Rakovic, N.
    Abu Rabi, Z.
    [J]. EUROPEAN JOURNAL OF CANCER, 2013, 49 : S476 - S476
  • [30] Beta-catenin has a central role in melanoma progression
    Sinnberg, T.
    Menzel, M.
    Ewerth, D.
    Schaller, M.
    Garbe, C.
    Schittek, B.
    [J]. EXPERIMENTAL DERMATOLOGY, 2011, 20 (02) : 200 - 200
12345