Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression

被引：82
|
作者：
Dejonckheere, Eline [1 ,2 ]
Vandenbroucke, Roosmarijn E. [1 ,2 ]
Libert, Claude [1 ,2 ]
机构：
[1] VIB, DBMR, Dept Mol Biomed Res, B-9052 Ghent, Zwijnaarde, Belgium
[2] Univ Ghent, Dept Mol Biol, B-9000 Ghent, Belgium
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 02期
关键词：
MMP8; Inflammation; Cancer; GINGIVAL CREVICULAR FLUID; COLLAGENASE-2; MMP-8; EXPRESSION; IN-VIVO; TISSUE INHIBITOR; NEUTROPHIL COLLAGENASE; CHRONIC PERIODONTITIS; ADULT PERIODONTITIS; INDUCED SPUTUM; PLASMA-LEVELS; UP-REGULATION;
D O I：
10.1016/j.cytogfr.2011.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover, modulation of inflammatory responses and other physiological processes is well documented. Several recent studies highlight the involvement of MMP8 in a wide range of pathologies. This review will shed light on the putative role of MMP8 as a drug target or disease marker in some inflammatory disorders and in cancer progression. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：73 / 81
页数：9
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