Passive immunization as prophylaxis: when and where will this work?

被引：16
|
作者：
Dunman, PM
Nesin, M
机构：
[1] Wyeth, Bacterial Vaccines, Pearl River, NY 10965 USA
[2] Cornell Univ, Dept Pediat, Div Neonatol, Weill Med Coll,Perinatol Ctr N506, New York, NY 10021 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 05期
关键词：
D O I：
10.1016/j.coph.2003.05.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The strict definition of passive immunoprophylaxis includes the administration of exogenously produced antibodies (polyclonal and monoclonal) to prevent infections in exposed individuals, inactivate bacterial toxins or 'correct' hypogammaglobulinemia in immunocompromised hosts. This definition can be broadened to include modulators of the immune system. Despite advances in chemotherapy and vaccine development, suitable treatment is not currently available for many pathogens. As a result, passive immunization is an appropriate therapeutic option for many organisms.
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页码：486 / 496
页数：11
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