Prognostic Biomarkers for Melanoma Immunotherapy

被引：11

作者：

Twitty, Christopher G. ^{[1
]}

Huppert, Laura A. ^{[2
]}

Daud, Adil I. ^{[2
]}

机构：

[1] OncoSec Inc, 3565 Gen Atom Ct, San Diego, CA 92121 USA

[2] Univ Calif San Francisco, Dept Med, Div Hematol Oncol, 1600 Divisadero St,Rm A741, San Francisco, CA 94143 USA

来源：

CURRENT ONCOLOGY REPORTS | 2020年 / 22卷 / 03期

关键词：

Immune checkpoint inhibitors; Programmed death-1 (PD-1); Programmed death ligand-1 (PD-L1); Exhausted T cells (Tex); Tumor microenvironment (TME); Memory T cells (Tmem); Tumor mutation burden; Circulating tumor DNA; TUMOR-INFILTRATING LYMPHOCYTES; LIGAND; EXPRESSION; PD-1; BLOCKADE; MUTATIONAL LANDSCAPE; COMBINED NIVOLUMAB; PREDICTS RESPONSE; UVEAL MELANOMA; B7; FAMILY; T-CELLS; CANCER;

D O I：

10.1007/s11912-020-0886-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of Review Recent developments in immunotherapy have transformed the landscape of melanoma therapy. Here, we review markers for response to immunotherapy. Recent Findings Current immunotherapies disable immune checkpoints on T cells and other immune cells and allow immune rejection of tumor. This process depends crucially on a preexisting response to the development of the melanoma. Here we describe the complexity of the anti-tumor immune response and the links to the development of markers that are currently used or under investigation in the clinic. We describe immune response biomarkers along with new developments that could translate into advances.

引用

页数：9

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