Multifunctional self-assembled polymeric nanoprobes for FRET-based ratiometric detection of mitochondrial H2O2 in living cells

被引：49
|
作者：
Qiao, Jing [1 ,2 ]
Liu, Zhi [1 ]
Tian, Ye [1 ]
Wu, Man [1 ]
Niu, Zhongwei [1 ]
机构：
[1] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 17期
基金：
中国国家自然科学基金;
关键词：
2-PHOTON FLUORESCENT-PROBE; HYDROGEN-PEROXIDE; IN-VIVO; REACTIVE OXYGEN; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; LIVE TISSUE; CHEMILUMINESCENCE; NANOPARTICLES; AGGREGATION;
D O I：
10.1039/c4cc09120e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A ratiometric, multifunctional nanoprobe was prepared consisting of a self-assembled polymeric micelle as the carrier, tetraphenylethene (TPE) as the donor, fluorescent boronate as the H2O2-responsive acceptor, and triphenylphosphonium as a mitochondria-targeted moiety. The assembled nanoparticles could detect both exogenous and endogenous mitochondrial H2O2 changes in living cells.
引用
收藏
页码：3641 / 3644
页数：4
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