DETERMINATION OF PHENOLIC COMPOUNDS, CYTOTOXIC, ANTIOXIDANT AND ANTICANDIDAL EFFECTS OF TRIBULUS TERRESTRIS L. (ZYGOPHYLLACEAE)

This study was investigated the potential cytotoxic, antioxidant and anticandidal activities of T terrestris in vitro. Both the fruit and aerial parts of the T terrestris extract showed a significant cytotoxic effects in a dose dependent manner on both HeLa and SKOV-3. However, both cells were more sensitive against the aerial parts of the T terrestris extract as compared to fruit parts. The results showed that 1050 values of the fruit and aerial parts of the T terrestris extract is 0.22 and 0.04 mg/ml in HeLa; 0.36 and 0.02 mg/ml in SKOV-3, respectively. Both part of T terrestris methanolic extract did not show remarkable anticandidal effects compared with Quercetin dihexoside and rutin were determined as the major compounds of the extracts. The high cytotoxic effects of aereal parts might be due to the amount of rutin and quercetin dihexoside flavonols, btit this issue are still needed to be further investigated.