Neurologic Complications in Patients with Cancer

被引：3

作者：

Holroyd, Kathryn B. ^{[1
]}

Rubin, Daniel B. ^{[2
]}

Vaitkevicius, Henrikas ^{[3
]}

机构：

[1] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Massachusetts Gen Hosp, Dept Neurol, 75 Francis St, Boston, MA 02115 USA

[3] Marinus Pharmaceut Inc, 5 Radnor Corp Ctr, 100 Matsonford Rd,Suite 500, Radnor, PA 19087 USA

来源：

SEMINARS IN NEUROLOGY | 2021年 / 41卷 / 05期

关键词：

metastases; paraneoplastic; CAR-T; immunotherapy; neurologic complications; REVERSIBLE ENCEPHALOPATHY SYNDROME; POSTERIOR LEUKOENCEPHALOPATHY SYNDROME; IFOSFAMIDE-INDUCED ENCEPHALOPATHY; IMMUNE CHECKPOINT INHIBITORS; T-CELL THERAPY; BRAIN METASTASES; ADVERSE EVENTS; LEPTOMENINGEAL METASTASES; RADIATION-THERAPY; INTRACRANIAL HEMORRHAGE;

D O I：

10.1055/s-0041-1733788

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurologic symptoms are commonly seen in patients with cancer and can be among the most challenging to diagnose and manage. It is often difficult to determine if new neurologic symptoms are secondary to direct effects of a malignant lesion, systemic complications of disease, paraneoplastic disorders, or side effects of cancer treatment itself. However, early diagnosis and treatment of each of these conditions can improve patients' quality of life and long-term functional outcomes. In this review, we describe a systematic approach to the diagnosis of new neurologic symptoms in patients with known malignancy. We have categorized the neurologic complications of cancer through a mechanistic approach, with an emphasis on ascertaining underlying pathophysiology to guide treatment choice. This review focuses on the acute neurologic complications of cancer that require hospital admission.

引用

页码：588 / 605

页数：18

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