Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids

被引：25

作者：

Olofsson, Louise E. ^{[1
]}

Olsson, Bob ^{[1
]}

Lystig, Theodore ^{[1
]}

Jacobson, Peter ^{[1
]}

Jernas, Margareta ^{[1
]}

Sjoholm, Kajsa ^{[1
]}

Gummesson, Anders ^{[1
]}

Sjostrom, Lars ^{[1
]}

Eriksson, Per ^{[2
]}

Hamsten, Anders ^{[2
]}

Hale, Laura P. ^{[3
]}

Thelle, Dag S. ^{[4
]}

Carlsson, Bjorn ^{[1
]}

Carlsson, Lena M. S. ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Sahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden

[2] Karolinska Univ Hosp, Karolinska Inst, Atherosclerosis Res Unit, King Gustaf V Res Inst, S-17176 Stockholm, Sweden

[3] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[4] Univ Oslo, Inst Basic Med Sci, Dept Biostat, N-0317 Oslo, Norway

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2010年 / 59卷 / 09期

基金：

瑞典研究理事会;

关键词：

METABOLIC SYNDROME; LIGAND-BINDING; ZINC-ALPHA-2-GLYCOPROTEIN; ZN-ALPHA(2)-GLYCOPROTEIN; ADIPOCYTES; LIPOLYSIS; CANCER; MICE;

D O I：

10.1016/j.metabol.2009.12.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man Serum levels of ZAG correlated with serum levels of cholesterol (P = 00088) in health), subjects and during weight loss (P = 059) The ZAG genotype was associated with total cholesterol (P = 014) and low-density lipoprotein cholesterol (P = 026) in healthy subjects, and the associations were replicated in an additional cohort (P = 0017 and P = (160, respectively) Our data indicate that ZAG plays a role in lipid metabolism (C) 2010 Elsevier Inc All rights reserved

引用

页码：1316 / 1318

页数：3

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