An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

被引：111
|
作者：
Jorm, AF [1 ]
Henderson, AS
Jacomb, PA
Christensen, H
Korten, AE
Rodgers, B
Tan, X
Easteal, S
机构：
[1] Australian Natl Univ, NHMRC Psychiat Epidemiol Res Ctr, Canberra, ACT 0200, Australia
[2] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
来源：
MOLECULAR PSYCHIATRY | 1998年 / 3卷 / 05期
关键词：
neuroticism; extraversion; psychoticism; anxiety; depression; alcohol abuse; genetics; serotonin transport;
D O I：
10.1038/sj.mp.4000424
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A functional polymorphism in the regulatory region of the serotonin transporter gene has been reported to be associated with anxiety-related personality traits.' We attempted to replicate this finding in an association study involving 759 Caucasians selected from the general Australian population. We found no associations with personality traits (including neuroticism, negative affect and behavioral inhibition), anxiety and depressive symptoms, or alcohol misuse.
引用
收藏
页码：449 / 451
页数：3
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