Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene

被引：43
|
作者：
Ohara, K [1 ]
Nagai, M [1 ]
Suzuki, Y [1 ]
Ochiai, M [1 ]
Ohara, K [1 ]
机构：
[1] Hamamatsu Univ Sch Med, Dept Psychiat, Hamamatsu, Shizuoka 43131, Japan
来源：
PSYCHIATRY RESEARCH | 1998年 / 81卷 / 02期
关键词：
anxiety disorder; serotonin transporter; promoter; functional polymorphism; gene; PCR;
D O I：
10.1016/S0165-1781(98)00100-0
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Recently, individuals with the short form of the serotonin transporter were found to be associated with neurotic characteristics. An association study on this polymorphism was performed in anxiety disorder patients and control subjects. The short form allele frequency in patients tended to be higher than that in control subjects (81.7 vs. 74.5%). Although it is difficult to ascribe significance to these 'tendencies', these data may suggest that variation of this functional polymorphism makes some contribution to anxiety disorders. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：277 / 279
页数：3
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