Investigation of the microprecipitation of folic acid from slightly acidic injection solutions using dynamic light scattering

被引：0
|
作者：
Kéki, S
Sipos, T
Deák, G
Mezey, G
Zsuga, M
机构：
[1] Lajos Kossuth Univ, Dept Appl Chem, H-4010 Debrecen, Hungary
[2] Lajos Kossuth Univ, Dept Pharmaceut Technol, H-4010 Debrecen, Hungary
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 08期
关键词：
dynamic light scattering; folic acid injection; folic acid precipitation; microprecipitation;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Microprecipitation of folic acid was monitored by the dynamic light scattering (DLS) method. The pH was changed by CO2 absorption and addition of HCl. The folic acid solutions were examined over the pH range 8.5-4.0. Over the pH range 5.4-6.0, microprecipitation was observed and at pH less than or equal to 5.2 crude precipitation of folic acid occurred. The dependence of the effective diameter on the pH over the pH range 5.4-6.0 is also reported.
引用
收藏
页码：1333 / 1334
页数：2
相关论文
共 50 条
  • [31] Dynamic light scattering from non-entangled wormlike micellar solutions
    Sato, Takahiro
    Einaga, Yoshiyuki
    LANGMUIR, 2008, 24 (01) : 57 - 61
  • [32] DYNAMIC LIGHT-SCATTERING FROM CONCENTRATED POLYMER-SOLUTIONS AND GELS
    PATTERSON, GD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1980, 180 (AUG): : 31 - COLL
  • [33] Static and dynamic light scattering from aqueous poly(ethylene oxide) solutions
    Venohr, H
    Fraaije, V
    Strunk, H
    Borchard, W
    EUROPEAN POLYMER JOURNAL, 1998, 34 (5-6) : 723 - 732
  • [34] STATIC AND DYNAMIC LIGHT-SCATTERING FROM SOLUTIONS OF POLYMERS WITH DIFFERING ARCHITECTURE
    COTTS, PM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 202 : 250 - POLY
  • [35] Dynamic light scattering and zeta potential investigation of fulvic and humic acid reversible self-assembly in low electrolytic conductivity solutions
    Wells, Martha
    Esfahani, Milad
    Stretz, Holly
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [36] Comparison of diffusion coefficients obtained from ternary polymer solutions using dynamic light scattering and ultra centrifugation
    Pinder, DN
    Ueleni, T
    Lewis, JA
    JOURNAL OF MOLECULAR STRUCTURE, 1996, 383 (1-3) : 107 - 115
  • [37] SEMIDILUTE SOLUTIONS OF POLY(METHACRYLIC ACID) IN THE ABSENCE OF SALT - DYNAMIC LIGHT-SCATTERING STUDY
    SEDLAK, M
    KONAK, C
    STEPANEK, P
    JAKES, J
    POLYMER, 1987, 28 (06) : 873 - 880
  • [38] INVESTIGATION OF LIGHT SCATTERING BY METAL TRIOXYFLUORONATE SOLUTIONS IN AN ALKALINE MEDIUM IN PRESENCE OF BORIC ACID.
    Fedin, A.V.
    Colloid Journal of the USSR (English Translation of Kolloidnyi Zhurnal), 1982, 44 (01): : 154 - 157
  • [39] Uncertainty analysis of measurements of the size of nanoparticles in aqueous solutions using dynamic light scattering
    Kwon, Su Yong
    Kim, Yong-Gyoo
    Lee, Sang Hyun
    Moon, Jun Hyuk
    METROLOGIA, 2011, 48 (05) : 417 - 425
  • [40] Investigation on the homogeneity of RAFT polymerized PMMA gels using dynamic light scattering and rheology
    Scherf, Robert
    Mueller, Lisa S.
    Grosch, Daniel
    Huebner, Eike G.
    Oppermann, Wilhelm
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
12345