Investigation of the microprecipitation of folic acid from slightly acidic injection solutions using dynamic light scattering

被引：0
|
作者：
Kéki, S
Sipos, T
Deák, G
Mezey, G
Zsuga, M
机构：
[1] Lajos Kossuth Univ, Dept Appl Chem, H-4010 Debrecen, Hungary
[2] Lajos Kossuth Univ, Dept Pharmaceut Technol, H-4010 Debrecen, Hungary
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 08期
关键词：
dynamic light scattering; folic acid injection; folic acid precipitation; microprecipitation;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Microprecipitation of folic acid was monitored by the dynamic light scattering (DLS) method. The pH was changed by CO2 absorption and addition of HCl. The folic acid solutions were examined over the pH range 8.5-4.0. Over the pH range 5.4-6.0, microprecipitation was observed and at pH less than or equal to 5.2 crude precipitation of folic acid occurred. The dependence of the effective diameter on the pH over the pH range 5.4-6.0 is also reported.
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页码：1333 / 1334
页数：2
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