Clinical Genetics of Hereditary Colorectal Cancer

被引：22

作者：

Power, Derek G. ^{[2
]}

Gloglowski, Emily ^{[2
]}

Lipkin, Steven M. ^{[1
]}

机构：

[1] Weill Cornell Coll Med, Dept Med, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2010年 / 24卷 / 05期

关键词：

Colorectal cancer; Genetics; Hereditary; Germline; Lynch syndrome; Mismatch repair; FAMILIAL ADENOMATOUS POLYPOSIS; MSH6 GERMLINE MUTATIONS; MICROSATELLITE INSTABILITY PREDICTS; GENOTYPE-PHENOTYPE CORRELATIONS; MISMATCH-REPAIR-DEFICIENCY; NONPOLYPOSIS COLON-CANCER; PEUTZ-JEGHERS-SYNDROME; SOCIETY-TASK-FORCE; LYNCH-SYNDROME; BRAF MUTATION;

D O I：

10.1016/j.hoc.2010.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is a common disease, and approximately 25% of patients have a familial component. High-penetrance singlegene germline mutations conferring a true hereditary susceptibility account for around 5% to 6% of all cases. Lynch syndrome is the most common hereditary form of colorectal cancer. Much of the hereditary component in the remaining familial cases of CRC is likely polygenic, and many of the genetic changes involved are as yet unidentified. This article addresses the most clinically important CRC genetic syndromes.

引用

页码：837 / +

页数：25

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