Cytokines and Chemokines in Neuropsychiatric Syndromes of Systemic Lupus Erythematosus

被引：48
|
作者：
Okamoto, Hiroshi [1 ,2 ]
Kobayashi, Akiko [1 ,2 ]
Yamanaka, Hisashi [1 ]
机构：
[1] Tokyo Womens Med Univ, Inst Rheumatol, Tokyo 1620054, Japan
[2] Minami Otsuka Clin, Minami Otsuka Inst Technol, Tokyo 1700005, Japan
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年
关键词：
CEREBROSPINAL-FLUID; RHEUMATOID-ARTHRITIS; SOLUBLE FRACTALKINE; MOLECULAR ASPECTS; INTERFERON-ALPHA; ELEVATED LEVELS; CNS LUPUS; INTERLEUKIN-6; INVOLVEMENT; MANIFESTATIONS;
D O I：
10.1155/2010/268436
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) is a life-threatening disorder and early diagnosis and proper treatment are critical in the management of this neuropsychiatric manifestations in lupus. Brain magnetic resonance imaging (MRI), electroencephalogram (EEG), neuropsychological tests, and lumbar puncture are clinical used for the diagnosis of NPSLE. In addition to these tests, cytokine and chemokine levels in CSF have been reported as useful diagnostic marker of NPSLE. Based on the number of recently published studies, this review overviewed the roles of cytokines and chemokines in NPSLE.
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页数：8
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