Expression of cocaine sensitization: Regulation by the medial prefrontal cortex

被引:50
|
作者
Prasad, BM [1 ]
Hochstatter, T [1 ]
Sorg, BA [1 ]
机构
[1] Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, Neurosci Program, Pullman, WA 99164 USA
关键词
dopamine; sensitization; cocaine; amphetamine; medial prefrontal cortex;
D O I
10.1016/S0306-4522(98)00183-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Extracellular levels of dopamine are increased in response to systemic administration of cocaine in several brain areas including the nucleus accumbens and medial prefrontal cortex. While the cocaine-induced increase in extracellular dopamine levels in the nucleus accumbens is augmented after repeated daily cocaine, the response of extracellular dopamine levels in the medial prefrontal cortex is attenuated. Since dopamine in the medial prefrontal cortex has an inhibitory effect on nucleus accumbens dopamine levels and locomotor activity, the role of medial prefrontal cortex dopamine tolerance in the expression of sensitized locomotor behavior was further examined by injection of D-amphetamine sulfate into the prelimbic portion of the medial prefrontal cortex just prior to cocaine challenge in cocaine-sensitized rats. Male Sprague-Dawley rats were non-handled (naive) or injected with either saline (1 ml/kg, i.p.) or cocaine (15 mg/kg, i.p.) for five consecutive days. After a seven to 12 day withdrawal period, rats were microinjected with either saline or various doses of amphetamine into primarily the prelimbic region of the medial prefrontal cortex follow ed by systemic injection of saline or cocaine. In naive rats, intramedial prefrontal cortex amphetamine produced a trend toward decreased locomotor responding to cocaine challenge while no effect of amphetamine was evident in daily saline pretreated rats. Daily cocaine pretreated rats that received saline in the medial prefrontal cortex demonstrated a sensitized locomotor response compared to their daily saline pretreated counterparts. This sensitization was blocked by a low dose of amphetamine (0.175 mu g/side) in the medial prefrontal cortex, an effect which disappeared in animals administered higher amphetamine doses. The results suggest that in rats sensitized to cocaine, decreased medial prefrontal cortex dopamine levels in response to cocaine challenge may contribute to behavioral sensitization. Furthermore, the data indicate the possibility that there is an optimal range at which medial prefrontal cortex amphetamine exerts maximal behavioral inhibition. These findings implicate a role for decreased cortical control in producing sensitized behavioral responding to cocaine. (C) 1998 IBRO. Published by Elsevier Science Ltd.
引用
收藏
页码:765 / 774
页数:10
相关论文
共 50 条
  • [41] Repeated cocaine and stress increase dopamine clearance in the rat medial prefrontal cortex
    Meiergerd, SM
    Schenk, JO
    Sorg, BA
    BRAIN RESEARCH, 1997, 773 (1-2) : 203 - 207
  • [42] Orexin/Hypocretin Signaling in the Medial Prefrontal Cortex in Rodent Models of Cocaine Addiction
    Avila, Jorge
    Gonzalez, Jocelynn
    Aston-Jones, Gary
    NEUROPSYCHOPHARMACOLOGY, 2021, 46 (SUPPL 1) : 427 - 427
  • [43] Beyond the Medial Regions of Prefrontal Cortex in the Regulation of Fear and Anxiety
    Shiba, Yoshiro
    Santangelo, Andrea M.
    Roberts, Angela C.
    FRONTIERS IN SYSTEMS NEUROSCIENCE, 2016, 10
  • [44] Microrna regulation in medial prefrontal cortex after nerve injury
    Kummer, K.
    Kalpachidou, T.
    Kress, M.
    JOURNAL OF NEUROCHEMISTRY, 2017, 142 : 91 - 91
  • [45] Medial prefrontal cortex and the adaptive regulation of reinforcement learning parameters
    Khamassi, Mehdi
    Enel, Pierre
    Dominey, Peter Ford
    Procyk, Emmanuel
    DECISION MAKING: NEURAL AND BEHAVIOURAL APPROACHES, 2013, 202 : 441 - 464
  • [46] Emotion regulation in spider phobia: role of the medial prefrontal cortex
    Hermann, Andrea
    Schaefer, Axel
    Walter, Bertram
    Stark, Rudolf
    Vaitl, Dieter
    Schienle, Anne
    SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2009, 4 (03) : 257 - 267
  • [47] Cocaine-Induced Behavioral Sensitization Is Associated With Changes in the Expression of Endocannabinoid and Glutamatergic Signaling Systems in the Mouse Prefrontal Cortex
    Blanco, Eduardo
    Pavon, Francisco J.
    Palomino, Ana
    Jesus Luque-Rojas, Maria
    Serrano, Antonia
    Rivera, Patricia
    Bilbao, Ainhoa
    Alen, Francisco
    Vida, Margarita
    Suarez, Juan
    Rodriguez de Fonseca, Fernando
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2015, 18 (01):
  • [48] PSA-NCAM expression in the rat medial prefrontal cortex
    Varea, E
    Nácher, J
    Blasco-Ibáñez, JM
    Gómez-Climent, MA
    Castillo-Gómez, E
    Crespo, C
    Martínez-Guijarro, FJ
    NEUROSCIENCE, 2005, 136 (02) : 435 - 443
  • [49] Sensitized Fos expression in subterritories of the rat medial prefrontal cortex and nucleus accumbens following amphetamine sensitization as revealed by stereology
    Hédou, G
    Jongen-Rêlo, AL
    Murphy, CA
    Heidbreder, CA
    Feldon, J
    BRAIN RESEARCH, 2002, 950 (1-2) : 165 - 179
  • [50] Prefrontal cortex and cocaine seeking
    不详
    NEUROSCIENTIST, 2013, 19 (05): : 432 - 432