X-Ray Computed Tomography Imaging of Breast Cancer by using Targeted Peptide-Labeled Bismuth Sulfide Nanoparticles

被引：191
|
作者：
Kinsella, Joseph M. [1 ]
Jimenez, Rebecca E.
Karmali, Priya P. [2 ,3 ]
Rush, Anthony M. [1 ]
Kotamraju, V. Ramana [2 ,3 ]
Gianneschi, Nathan C. [1 ]
Ruoslahti, Erkki [2 ,3 ]
Stupack, Dwayne
Sailor, Michael J. [1 ]
机构：
[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
[2] Univ Calif Santa Barbara, Ctr Nanomed, Sanford Burnham Med Res Inst, Santa Barbara, CA 93106 USA
[3] Canc Ctr Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 51期
基金：
美国国家卫生研究院;
关键词：
cancer; imaging agents; nanomedicine; nanoparticles; peptides; GOLD NANOPARTICLES; CONTRAST AGENT; HOMING PEPTIDE; QUANTUM DOTS; CELLS;
D O I：
10.1002/anie.201104507
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi 2S 3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260-% over non-labeled nanoparticles. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12308 / 12311
页数：4
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