Effect of cholesterol and CYP46 polymorphism on cognitive event-related potentials

被引：5

作者：

Lai, Chiou-lian ^{[1
,2
]}

Hsu, Chung-yao ^{[1
,2
]}

Liou, Li-min ^{[3
]}

Hsieh, Hsin-yi ^{[2
]}

Hsieh, Yi-hsing ^{[4
]}

Liu, Ching-kuan ^{[1
,2
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Fac Med, Coll Med, Dept Neurol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Neurol, Kaohsiung, Taiwan

[4] Natl Changhua Univ Educ, Dept Guidance & Counseling, Changhua, Taiwan

来源：

PSYCHOPHYSIOLOGY | 2011年 / 48卷 / 11期

关键词：

Cholesterol; CYP46; 24S-hydroxylase; Event-related potentials; P300; CARDIOVASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; METABOLISM; P300; 24-HYDROXYLASE; ASSOCIATION; VARIABILITY; DECLINE; AGE;

D O I：

10.1111/j.1469-8986.2011.01221.x

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of cholesterol and CYP46 genotypes on cognitive event-related potentials (ERPs). The subjects with a high low-density lipoprotein cholesterol (LDL-C) level displayed significantly lower amplitude ERPs, although the CASI scores showed no difference. There was no association between the CYP46 genotypes, CASI scores, cholesterol levels, and measures of ERPs. No interaction between LDL-C level and CYP46 genotypes was noted. The LDL-C level is an independent predictor of low P300 amplitude. Prevention and treatment of high cholesterol may be of potential benefit in reducing cognitive impairment.

引用

页码：1571 / 1576

页数：6

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