Synthesis and antimicrobial activity of some new thienopyrimidine derivatives

被引：15
|
作者：
Tolba, Mahmoud S. [1 ]
El-Dean, Adel M. Kamal [2 ]
Ahmed, Mostafa [1 ]
Hassanien, Reda [1 ]
Farouk, Mahmoud [1 ]
机构：
[1] Assiut Univ, New Valley Fac Sci, Chem Dept, Assiut 72511, Egypt
[2] Assiut Univ, Fac Sci, Chem Dept, Assiut 71516, Egypt
来源：
ARKIVOC | 2017年
关键词：
Antimicrobials; thienopyrimidine; pyrimidothienopyrimidine; fused tetrazoles; PYRIMIDINE-DERIVATIVES; BIOLOGICAL-ACTIVITY; KINASE INHIBITORS; THIENO; NUCLEOSIDES; ANTITUMOR; RECEPTOR; AGENTS;
D O I：
10.24820/ark.5550190.p010.226
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Due to the biological activities of pyrimidine and thienopyrimidine as antimicrobial agents, so in the present work, a series of new heterocyclic compounds containing thienopyrimidine moiety were synthesized such as, tetrazolo[1", 5": 1',6'] pyrimido[4',5': 4,5] thieno[2,3-d] pyrimidine derivatives (8-12b), pyrimido[3",2":1', 6'] pyrim-ido[ 4', 5': 4,5] thieno[2,3-d] pyrimidine derivatives (14,16) and pyrimido[5', 4': 4,5] thieno[2,3-e] pyrimido[1,2-c] [1,2,3] triazine derivative (15) by using 5-amino-4-phenyl-2-(p-tolylamino) thieno[ 2,3-d] pyrimidine-6-carbonitrile (7) as starting material. All synthesized compounds were evaluated for their antimicrobial activity. And Compounds (8-13) exhibited high antibacterial activity. Also, compounds (12b-18) exhibited high antifungal activity.
引用
收藏
页码：229 / 243
页数：15
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