Synthesis and antimicrobial activity of some new thienopyrimidine derivatives

被引：15

作者：

Tolba, Mahmoud S. ^{[1
]}

El-Dean, Adel M. Kamal ^{[2
]}

Ahmed, Mostafa ^{[1
]}

Hassanien, Reda ^{[1
]}

Farouk, Mahmoud ^{[1
]}

机构：

[1] Assiut Univ, New Valley Fac Sci, Chem Dept, Assiut 72511, Egypt

[2] Assiut Univ, Fac Sci, Chem Dept, Assiut 71516, Egypt

来源：

ARKIVOC | 2017年

关键词：

Antimicrobials; thienopyrimidine; pyrimidothienopyrimidine; fused tetrazoles; PYRIMIDINE-DERIVATIVES; BIOLOGICAL-ACTIVITY; KINASE INHIBITORS; THIENO; NUCLEOSIDES; ANTITUMOR; RECEPTOR; AGENTS;

D O I：

10.24820/ark.5550190.p010.226

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Due to the biological activities of pyrimidine and thienopyrimidine as antimicrobial agents, so in the present work, a series of new heterocyclic compounds containing thienopyrimidine moiety were synthesized such as, tetrazolo[1", 5": 1',6'] pyrimido[4',5': 4,5] thieno[2,3-d] pyrimidine derivatives (8-12b), pyrimido[3",2":1', 6'] pyrim-ido[ 4', 5': 4,5] thieno[2,3-d] pyrimidine derivatives (14,16) and pyrimido[5', 4': 4,5] thieno[2,3-e] pyrimido[1,2-c] [1,2,3] triazine derivative (15) by using 5-amino-4-phenyl-2-(p-tolylamino) thieno[ 2,3-d] pyrimidine-6-carbonitrile (7) as starting material. All synthesized compounds were evaluated for their antimicrobial activity. And Compounds (8-13) exhibited high antibacterial activity. Also, compounds (12b-18) exhibited high antifungal activity.

引用

页码：229 / 243

页数：15

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