Anti-CRISPR proteins: Counterattack of phages on bacterial defense (CRISPR/Cas) system

被引：6
|
作者：
Chaudhary, Kulbhushan [1 ]
Chattopadhyay, Anirudha [2 ]
Pratap, Dharmendra [3 ]
机构：
[1] Indian Agr Res Inst, Div Plant Pathol, Adv Ctr Plant Virol, New Delhi 110012, India
[2] SD Agr Univ, Dept Plant Pathol, CP Coll Agr, S K Nagar, Gujrat, India
[3] Chaudhary Charan Singh Univ, Dept Genet & Plant Breeding, Meerut, Uttar Pradesh, India
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 01期
关键词：
anti-CRISPR proteins; bacteriophage; CASCADE; CRISPR; genome editing; ESCHERICHIA-COLI; IMMUNE-SYSTEM; ARMS-RACE; INHIBITION; SEQUENCE; INSIGHTS; MECHANISMS; GENE;
D O I：
10.1002/jcp.25877
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Since the dawn of life there is a never ending strife between bacteria and phages. Both are perpetually changing their strategies to take over each other. CRISPR/Cas is the most widespread defense system used by bacteria against mobile genetic elements (MGEs) such as phages, cojugative palsmids, transoposons, and pathogenicity islands. This system utilizes small guide RNA molecules to protect against phages infection and invasion by MGEs. Phages circumvent to these antiviral barriers by point mutation in PAM (protospacer-adjacent motif) sequence, genome rearrangements and by using anti-CRISPR proteins.
引用
收藏
页码：57 / 59
页数：3
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