Haldane's formula in Cannings models: the case of moderately strong selection

被引:5
|
作者
Boenkost, Florin [1 ]
Gonzalez Casanova, Adrian [2 ]
Pokalyuk, Cornelia [1 ]
Wakolbinger, Anton [1 ]
机构
[1] Goethe Univ Frankfurt, FB 12, D-60054 Frankfurt, Germany
[2] Univ Nacl Autonoma Mexico, Inst Matemat, Area Invest Cient, Ciudad Univ, Cdmx 04510, Mexico
关键词
Branching process approximation; Cannings model; Directional selection; Probability of fixation; SURVIVAL PROBABILITY; MUTANT; FIXATION; RATES;
D O I
10.1007/s00285-021-01698-9
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
For a class of Cannings models we prove Haldane's formula, pi(s(N)) similar to 2s(N)/rho(2), for the fixation probability of a single beneficial mutant in the limit of large population size N and in the regime of moderately strong selection, i.e. for s(N) similar to N-b and 0 < b < 1/2. Here, s(N) is the selective advantage of an individual carrying the beneficial type, and rho(2) is the (asymptotic) offspring variance. Our assumptions on the reproduction mechanism allow for a coupling of the beneficial allele's frequency process with slightly supercritical Galton-Watson processes in the early phase of fixation.
引用
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页数:31
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