Efficacy of mechanisms of neuroplasticity after a stroke

被引:10
|
作者
Cabral, Danylo F. [1 ]
Fried, Peter [2 ]
Koch, Sebastian [3 ]
Rice, Jordyn [1 ]
Rundek, Tatjana [3 ,4 ]
Pascual-Leone, Alvaro [5 ,6 ,7 ]
Sacco, Ralph [3 ,4 ]
Wright, Clinton B. [8 ]
Gomes-Osman, Joyce [1 ,3 ,4 ]
机构
[1] Univ Miami, Dept Phys Therapy, Coral Gables, FL 33124 USA
[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA USA
[3] Univ Miami, Dept Neurol, Miami, FL 33136 USA
[4] Univ Miami, Evelyn McKnight Brain Inst, Miami, FL 33136 USA
[5] Harvard Med Sch, Dept Neurol, Boston, MA USA
[6] Hebrew SeniorLife, Hinda & Arthur Marcus Inst Aging Res & Deanna & S, Rosindale, MA USA
[7] Guttmann Brain Hlth Inst, Barcelona, Spain
[8] NINDS, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
Mechanism of neuroplasticity; transcranial magnetic stimulation; iTBS; functional capacity; motor function; stroke; THETA-BURST-STIMULATION; BRAIN PLASTICITY; RECOVERY;
D O I
10.3233/RNN-211227
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The sequelae of stoke, including the loss and recovery of function, are strongly linked to the mechanisms of neuroplasticity. Rehabilitation and non-invasive brain stimulation (NIBS) paradigms have shown promise in modulating corticomotor neuroplasticity to promote functional recovery in individuals post-stroke. However, an important limitation to these approaches is that while stroke recovery depends on the mechanisms of neuroplasticity, those mechanisms may themselves be altered by a stroke. Objective: Compare Transcranial Magnetic Stimulation (TMS)-based assessments of efficacy of mechanism of neuroplasticity between individuals post-stroke and age-matched controls. Methods: Thirty-two participants (16 post-stroke, 16 control) underwent an assessment of mechanisms of neuroplasticity, measured by the change in amplitude of motor evoked potentials elicited by single-pulse TMS 10-20 minutes following intermittent theta-burst stimulation (iTBS), and dual-task effect (DTE) reflecting cognitive-motor interference (CMI). In stroke participants, we further collected: time since stroke, stroke type, location, and Stroke Impact Scale 16 (SIS-16). Results: Although there was no between-group difference in the efficacy of TMS-iTBS neuroplasticity mechanism (p = 0.61, eta(2) = 0.01), the stroke group did not exhibit the expected facilitation to TMS-iTBS (p = 0.60, eta(2) = 0.04) that was shown in the control group (p = 0.016, eta(2) 0.18). Sub-cohort analysis showed a trend toward a difference between those in the latestage post-stroke and the control group (p = 0.07, eta(2) = 0.12). Within the post-stroke group, we found significant relationships between TMS-iTBS neuroplasticity and time since stroke onset, physical function (SIS-16), and CMI (all rs > vertical bar 0.53 vertical bar and p-values < 0.05). Conclusions: In this proof-of-principle study, our findings suggested altered mechanisms of neuroplasticity in post-stroke patients which were dependent on time since stroke and related to motor function. TMS-iTBS neuroplasticity assessment and its relationship with clinical functional measures suggest that TMS may be a useful tool to study post-stroke recovery. Due to insufficient statistical power and high variability of the data, generalization of the findings will require replication of the results in a larger, better-characterized cohort.
引用
收藏
页码:73 / 84
页数:12
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