Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings

被引：1
|
作者：
Sakakibara, Tomohiro [1 ]
Saijo, Yasuo [2 ]
Fukuhara, Tatsuro [1 ]
Gomi, Kazunori [1 ]
Inoue, Akira [1 ]
Ishimoto, Osamu [3 ]
Sugawara, Shunichi [3 ]
Nukiwa, Toshihiro [1 ]
机构：
[1] Tohoku Univ, Inst Dev Aging & Canc, Dept Resp Oncol & Mol Med, Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Grad Sch Med, Dept Mol Med, Sendai, Miyagi 9808575, Japan
[3] Sendai Kousei Hosp, Dept Resp Med, Sendai, Miyagi, Japan
来源：
JOURNAL OF THORACIC ONCOLOGY | 2008年 / 3卷 / 03期
关键词：
non-small cell lung cancer; Familial lung cancer; Epidermal growth factor receptor (EGFR) gene mutation; EGFR tyrosine kinase inhibitor;
D O I：
10.1097/JTO.0b013e3181653cce
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sensitivity to an inhibitor of epidermal growth factor receptor (EGFR) kinase strongly correlates with EGFR somatic mutations in non-small cell lung cancer. These mutations are frequently found in patients with adenocarcinoma, never- or light-smokers, women, and East Asians. In this study, we show an aggregation of three non-small cell lung cancer cases with EGFR gene mutations in one family. The subjects were all female, never- or light-smokers with adenocarcinoma. Two of the patients responded to treatment with gefitimb. A genetic study of these cases would be useful in elucidating genetic susceptibility to lung cancer in persons with EGFR mutations.
引用
收藏
页码：311 / 313
页数：3
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