Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings

被引：1

作者：

Sakakibara, Tomohiro ^{[1
]}

Saijo, Yasuo ^{[2
]}

Fukuhara, Tatsuro ^{[1
]}

Gomi, Kazunori ^{[1
]}

Inoue, Akira ^{[1
]}

Ishimoto, Osamu ^{[3
]}

Sugawara, Shunichi ^{[3
]}

Nukiwa, Toshihiro ^{[1
]}

机构：

[1] Tohoku Univ, Inst Dev Aging & Canc, Dept Resp Oncol & Mol Med, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Mol Med, Sendai, Miyagi 9808575, Japan

[3] Sendai Kousei Hosp, Dept Resp Med, Sendai, Miyagi, Japan

来源：

JOURNAL OF THORACIC ONCOLOGY | 2008年 / 3卷 / 03期

关键词：

non-small cell lung cancer; Familial lung cancer; Epidermal growth factor receptor (EGFR) gene mutation; EGFR tyrosine kinase inhibitor;

D O I：

10.1097/JTO.0b013e3181653cce

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sensitivity to an inhibitor of epidermal growth factor receptor (EGFR) kinase strongly correlates with EGFR somatic mutations in non-small cell lung cancer. These mutations are frequently found in patients with adenocarcinoma, never- or light-smokers, women, and East Asians. In this study, we show an aggregation of three non-small cell lung cancer cases with EGFR gene mutations in one family. The subjects were all female, never- or light-smokers with adenocarcinoma. Two of the patients responded to treatment with gefitimb. A genetic study of these cases would be useful in elucidating genetic susceptibility to lung cancer in persons with EGFR mutations.

引用

页码：311 / 313

页数：3

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