Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity

被引：22
|
作者：
Siddiqui, Ruqaiyyah
Matin, Abdul
Warhurst, David
Stins, Monique
Khan, Naveed Ahmed [1 ]
机构：
[1] Univ London Birkbeck Coll, Sch Biol & Chem Sci, London WC1E 7HX, England
[2] Univ London, London Sch Hyg & Trop Med, London, ON, Canada
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 12期
关键词：
D O I：
10.1128/AAC.00373-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.
引用
收藏
页码：4471 / 4473
页数：3
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