Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments

被引：78

作者：

Gisbert, J. P. ^{[1
]}

Romano, M. ^{[2
]}

Gravina, A. G. ^{[3
]}

Solis-Munoz, P. ^{[4
]}

Bermejo, F. ^{[5
]}

Molina-Infante, J. ^{[6
]}

Castro-Fernandez, M. ^{[7
,8
]}

Ortuno, J. ^{[8
,9
]}

Lucendo, A. J. ^{[10
]}

Herranz, M. ^{[11
]}

Modolell, I. ^{[12
]}

del Castillo, F. ^{[13
]}

Gomez, J. ^{[14
]}

Barrio, J. ^{[15
]}

Velayos, B. ^{[16
]}

Gomez, B. ^{[17
]}

Dominguez, J. L. ^{[18
]}

Miranda, A. ^{[2
]}

Martorano, M. ^{[3
]}

Algaba, A. ^{[3
]}

Pabon, M. ^{[7
,8
]}

Angueira, T. ^{[10
]}

Fernandez-Salazar, L. ^{[16
]}

Federico, A. ^{[2
]}

Marin, A. C. ^{[1
]}

McNicholl, A. G. ^{[1
]}

机构：

[1] Hosp Univ Princesa, Gastroenterol Unit, Inst Invest Sanitaria Princesa, CIBEREHD, Madrid, Spain

[2] Seconda Univ Napoli, Naples, Italy

[3] Osped PO Immacolata, Sapri, Italy

[4] Angloamer Med Unit, Madrid, Spain

[5] Hosp Fuenlabrada, Madrid, Spain

[6] Hosp San Pedro de Alcantara, Caceres, Spain

[7] Hosp Valme, Seville, Spain

[8] CIBEREHD, Madrid, Spain

[9] Hosp La Fe, E-46009 Valencia, Spain

[10] Hosp Gen Tomelloso, Ciudad Real, Spain

[11] Hosp N Sra Sonsoles, Avila, Spain

[12] Consorci Sanitari Terrassa, Barcelona, Spain

[13] Hosp Don Benito, Badajoz, Spain

[14] Hosp Gregorio Maranon, Madrid, Spain

[15] Hosp Rio Hortega, Valladolid, Spain

[16] Hosp Clin, Valladolid, Spain

[17] Hosp Quiron Sagrado Corazon, Seville, Spain

[18] Alto Guadalquivir, Jaen, Spain

来源：

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2015年 / 41卷 / 08期

关键词：

CONCOMITANT THERAPY; SEQUENTIAL THERAPY; ERADICATION; INFECTION; RESISTANCE; EFFICACY; SUBCITRATE; CLARITHROMYCIN; METAANALYSIS; ANTIBIOTICS;

D O I：

10.1111/apt.13128

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundThe most commonly used second-line Helicobacter pylori eradication regimens are bismuth-containing quadruple therapy and levofloxacin-containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens. AimsTo evaluate the efficacy and tolerability of a second-line quadruple regimen containing levofloxacin and bismuth in patients whose previous H. pylori eradication treatment failed. MethodsThis was a prospective multicenter study including patients in whom a standard triple therapy (PPI-clarithromycin-amoxicillin) or a non-bismuth quadruple therapy (PPI-clarithromycin-amoxicillin-metronidazole, either sequential or concomitant) had failed. Esomeprazole (40mg b.d.), amoxicillin (1g b.d.), levofloxacin (500mg o.d.) and bismuth (240mg b.d.) was prescribed for 14days. Eradication was confirmed by C-13-urea breath test. Compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by questionnaires. Results200 patients were included consecutively (mean age 47years, 67% women, 13% ulcer). Previous failed therapy included: standard clarithromycin triple therapy (131 patients), sequential (32) and concomitant (37). A total of 96% took all medications correctly. Per-protocol and intention-to-treat eradication rates were 91.1% (95%CI=87-95%) and 90% (95%CI=86-94%). Cure rates were similar regardless of previous (failed) treatment or country of origin. Adverse effects were reported in 46% of patients, most commonly nausea (17%) and diarrhoea (16%); 3% were intense but none was serious. ConclusionsFourteen-day bismuth- and levofloxacin-containing quadruple therapy is an effective (90% cure rate), simple and safe second-line strategy in patients whose previous standard triple or non-bismuth quadruple (sequential or concomitant) therapies have failed.

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页码：768 / 775

页数：8

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