Diterpenes from Coleus forskohlii (WILLD.) BRIQ. (Labiatae)

被引：13

作者：

Shan, Yupei ^{[1
]}

Xu, Lingling ^{[1
]}

Lu, Yang ^{[2
]}

Wang, Xiaobing ^{[1
]}

Zheng, Qitai ^{[2
]}

Kong, Lingyi ^{[1
]}

Niwa, Masatake ^{[3
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 01期

关键词：

Coleus forskohlii; labiatae; forskoditerpenoside C; forskoditerpenoside D; forskoditerpenoside E; forskoditerpene A;

D O I：

10.1248/cpb.56.52

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new minor labdane diterpene glycosides, forskoditerpenoside C, D, and E (1 - 3), and a novel labdane diterpene forskoditerpene A (4) were isolated from the ethanol extract of the whole plant of Coleus forskohlii. Their structures and relative stereochemistry were elucidated on the basis of extensive spectroscopic analyses including 1D-, 2D-NMR, and HR-ESI-MS experiments. Compounds 1 - 3 showed an unusual 8,13-epoxy-labd-14-en-11-one glycoside pattern. They showed relaxative effects on isolated guinea pig tracheal spirals in vitro. Compound 4 with a cyclopropyl, confirmed by a single-crystal X-ray diffraction determination, is the first known labdane derivative with a spiro element.

引用

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页码：52 / 56

页数：5

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