A Study of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate, for Patients with Frontline and Relapsed/Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

被引:3
|
作者
Pemmaraju, Naveen
Marconi, Giovanni
Todisco, Elisabetta
Montesinos, Pau
Lane, Andrew A.
Sweet, Kendra
Wang, Eunice S.
Deconinck, Eric
Rizzieri, David A.
Walter, Roland B.
Aribi, Ahmed
Lebon, Delphine
Levy, Moshe Y.
Mazzarella, Luca
Martinelli, Giovanni
Gigli, Federica
Erba, Harry P.
Acuna-Cruz, Evelyn
Konopleva, Marina
Kantarjian, Hagop
Sloss, Callum M.
Wang, Jiuzhou
Malcolm, Kara E.
Zweidler-McKay, Patrick A.
DeAngelo, Daniel J.
Daver, Naval
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[2] Ist Seragnoli, Bologna, Italy
[3] European Inst Oncol IRCCS, Div Onco Hematol, Milan, Italy
[4] Hosp Univ & Politecn La Fe, Valencia, Spain
[5] Dana Farber Boston Childrens Canc & Blood Disorde, Dept Med Oncol, Boston, MA USA
[6] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA
[7] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA
[8] Besancon Univ Hosp, Clin Hematol, Besancon, France
[9] Duke Univ Med Ctr, Div Hematol Malignancies & Cellular Therapy, Dept Med, Durham, NC USA
[10] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
[11] City Hope Natl Med Ctr, Gehr Family Ctr Leukemia Res, Duarte, CA USA
[12] CHU Amiens, Hematol Dept, Amiens, France
[13] Texas Oncol Baylor Charles A Sammons Canc Ctr, Dallas, TX USA
[14] European Inst Oncol, Milan, Italy
[15] Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, Bologna, Italy
[16] European Inst Oncol, Milan, Italy
[17] Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA
[18] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[19] ImmunoGen, Waltham, MA USA
[20] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
关键词
D O I
10.1182/blood-2021-146681
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4429
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors
    Manisha H. Shah
    Paul Lorigan
    Mary E. R. O’Brien
    Frank V. Fossella
    Kathleen N. Moore
    Shailender Bhatia
    Maurice Kirby
    Penella J. Woll
    Investigational New Drugs, 2016, 34 : 290 - 299
  • [42] Objective responses in a phase I dose-escalation study of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in patients with relapsed or refractory Hodgkin lymphoma
    Younes, A.
    Forero-Torres, A.
    Bartlett, N. L.
    Leonard, J. P.
    Rege, B.
    Kennedy, D. A.
    Lorenz, J. M.
    Sievers, E. L.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [43] Objective responses in a phase I dose-escalation study of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in patients with relapsed or refractory Hodgkin lymphoma
    Younes, A.
    Forero-Torres, A.
    Bartlett, N. L.
    Leonard, J. P.
    Rege, B.
    Kennedy, D. A.
    Lorenz, J. M.
    Sievers, E. L.
    ANNALS OF ONCOLOGY, 2008, 19 : 129 - 129
  • [44] Safety, tolerability, and preliminary activity of IMGN529, a CD37-targeted antibody-drug conjugate, in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: a dose-escalation, phase I study
    Anastasios Stathis
    Ian W. Flinn
    Sumit Madan
    Kami Maddocks
    Arnold Freedman
    Steven Weitman
    Emanuele Zucca
    Mihaela C. Munteanu
    M. Lia Palomba
    Investigational New Drugs, 2018, 36 : 869 - 876
  • [45] Safety, tolerability, and preliminary activity of IMGN529, a CD37-targeted antibody-drug conjugate, in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: a dose-escalation, phase I study
    Stathis, Anastasios
    Flinn, Ian W.
    Madan, Sumit
    Maddocks, Kami
    Freedman, Arnold
    Weitman, Steven
    Zucca, Emanuele
    Munteanu, Mihaela C.
    Palomba, M. Lia
    INVESTIGATIONAL NEW DRUGS, 2018, 36 (05) : 869 - 876
  • [46] BT062, An Antibody-Drug Conjugate Directed Against CD138, Shows Clinical Activity In a Phase I Study in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma
    Jagannath, Sundar
    Chanan-Khan, Asher A.
    Heffner, Leonard T.
    Avigan, David
    Lutz, Robert J.
    Uherek, Christoph
    Osterroth, Frank
    Ruehle, Markus
    Haeder, Thomas
    Niemann, Gabriele
    Wartenberg-Demand, Andrea
    Munshi, Nikhil C.
    Anderson, Kenneth C.
    BLOOD, 2010, 116 (21) : 1262 - 1262
  • [47] Preliminary Results of a Phase 2 Study of Camidanlumab Tesirine (Cami), a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients with Relapsed or Refractory Hodgkin Lymphoma
    Herrera, Alex F.
    Carlo-Stella, Carmelo
    Collins, Graham P.
    Maddocks, Kami J.
    Bartlett, Nancy L.
    Savage, Kerry J.
    Caimi, Paolo F.
    Hess, Brian T.
    Zinzani, Pier Luigi
    Cruz, Hans G.
    Wang, Luqiang
    Feingold, Jay
    Wuerthner, Jens
    Ansell, Stephen M.
    BLOOD, 2020, 136
  • [48] Preliminary Results of a Phase 2 Study of Camidanlumab Tesirine (Cami), a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients With Relapsed or Refractory Hodgkin Lymphoma
    Herrera, Alex F.
    Carlo-Stella, Carmelo
    Collins, Graham P.
    Maddocks, Kami J.
    Bartlett, Nancy L.
    Savage, Kerry J.
    Caimi, Paolo F.
    Hess, Brian T.
    Zinzani, Pier Luigi
    Cruz, Hans G.
    Wang, Luqiang
    Feingold, Jay
    Wuerthner, Jens
    Ansell, Stephen M.
    CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, 2021, 19 (02) : 13 - 14
  • [49] Phase I Study of the Anti-CD22 Antibody-Drug Conjugate Pinatuzumab Vedotin with/without Rituximab in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
    Advani, Ranjana H.
    Lebovic, Daniel
    Chen, Andy
    Brunvand, Mark
    Goy, Andre
    Chang, Julie E.
    Hochberg, Ephraim
    Yalamanchili, Sreeni
    Kahn, Robert
    Lu, Dan
    Agarwal, Priya
    Dere, Randall C.
    Hsieh, Hsin-Ju
    Jones, Surai
    Chu, Yu-Waye
    Cheson, Bruce D.
    CLINICAL CANCER RESEARCH, 2017, 23 (05) : 1167 - 1176
  • [50] Preliminary findings from a phase I, multicenter, open-label study of the anti-CD37 antibody-drug conjugate (ADC), IMGN529, in adult patients with relapsed or refractory non-Hodgkin lymphoma (NHL).
    Stathis, Anastasios
    Maddocks, Kami J.
    Flinn, Ian
    Mejia, Alex
    Palomba, Maria Lia
    Zildjian, Sybil
    Murphy, Mary
    Deckert, Jutta
    Ruiz-Soto, Rodrigo
    Freedman, Arnold
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)