Line-field confocal time-domain optical coherence tomography with dynamic focusing

A time-domain optical coherence tomography technique is introduced for high-resolution B-scan imaging in real-time. The technique is based on a two-beam interference microscope with line illumination and line detection using a broadband spatially coherent light source and a line-scan camera. Multiple (2048) A-scans are acquired in parallel by scanning the sample depth while adjusting the focus. Quasi-isotropic spatial resolution of 1.3 mu m x 1.1 mu m (lateral x axial) is achieved. In vivo cellular-level resolution imaging of human skin is demonstrated at 10 frames per second with a penetration depth of similar to 500 mu m. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement