Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test

被引：24

作者：

Tadokoro, Koh ^{[1
]}

Yamashita, Toru ^{[1
]}

Fukui, Yusuke ^{[1
,2
]}

Nomura, Emi ^{[1
]}

Ohta, Yasuyuki ^{[1
]}

Ueno, Setsuko ^{[3
]}

Nishina, Saya ^{[3
]}

Tsunoda, Keiichiro ^{[1
,3
]}

Wakutani, Yosuke ^{[3
]}

Takao, Yoshiki ^{[3
]}

Miyoshi, Takahiro ^{[4
]}

Higashi, Yasuto ^{[4
]}

Osakada, Yosuke ^{[1
]}

Sasaki, Ryo ^{[1
]}

Matsumoto, Namiko ^{[1
]}

Kawahara, Yuko ^{[1
]}

Omote, Yoshio ^{[1
]}

Takemoto, Mami ^{[1
]}

Hishikawa, Nozomi ^{[1
]}

Morihara, Ryuta ^{[1
]}

Abe, Koji ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama, Japan

[2] Natl Hosp Org Shikoku Med Ctr Children & Adults, Dept Clin Res, Zentsuji, Japan

[3] Kurashiki Heisei Hosp, Dept Neurol, Kurashiki, Okayama, Japan

[4] Himeji Cent Hosp, Dept Neurol, Himeji, Hyogo 6728501, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2021年 / 427卷

关键词：

Alzheimer's disease; Cognitive assessment; Eye tracking technology; Mild cognitive impairment; MINI-MENTAL-STATE; VISUOSPATIAL ATTENTION; DEMENTIA; MOVEMENTS;

D O I：

10.1016/j.jns.2021.117529

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Due to an increasing number of dementia patients, the development of a rapid and sensitive method for cognitive assessment is awaited. Here, we examined the usefulness of a novel and short (3 min) eye tracking device to evaluate the cognitive function of normal control (NC, n = 52), mild cognitive impairment (MCI, n = 52), and Alzheimer's disease (AD, n = 70) subjects. Eye tracking total score declined significantly in MCI (**p < 0.01 vs NC) and AD (**p < 0.01 vs NC, ##p < 0.01 vs MCI), and correlated well with the mini-mental state examination (MMSE) score (r = 0.57, *p < 0.05). Furthermore, the eye tracking test, especially memory and deductive reasoning tasks, effectively discriminated NC, MCI and AD. The present novel eye tracking test clearly discriminated cognitive functions among NC, MCI, and AD subjects, thereby providing an advantage for the early detection of MCI and AD in screening.

引用

页数：7

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