Adenovirus vector-mediated gene transfer into stem cells

被引：37
|
作者：
Kawabata, Kenji [1 ]
Sakurai, Funlinori [1 ]
Koizumi, Naoya [1 ]
Hayakawa, Takao [2 ]
Mizuguchi, Hiroyuki [1 ,3 ]
机构：
[1] Natl Inst Biomed Innovat, Lab Gene Transfer & Regulat, Osaka 5670085, Japan
[2] Pharmaceut & Med Devices Agcy, Tokyo 1000013, Japan
[3] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka 5650871, Japan
来源：
MOLECULAR PHARMACEUTICS | 2006年 / 3卷 / 02期
关键词：
adenovirus; stem cell; gene therapy; regenerative medicine; review;
D O I：
10.1021/mp0500925
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Stem cells, including embryonic stem (ES) cells, mesenchymal stem cells (MSCs), and hematopoietic stem cells (HSCs), are defined by their capacity for self-renewal and multilineage differentiation. Efficient gene transfer into stem cells is essential for the basic research in developmental biology and for therapeutic applications in gene-modified regenerative medicine. Adenovirus (Ad) vectors, based on Ad type 5, can efficiently and transiently introduce the exogenous gene into many cell types via the primary receptor, coxsackievirus, and adenovirus receptor (CAR). However, some kinds of stem cells, such as MSCs and HSCs, cannot be efficiently transduced with conventional Ad vectors based on Ad serotype 5 (Ad5), because of the lack of CAR expression. To overcome this problem, fiber-modified Ad vectors and an Ad vector based on another serotype of Ad have been developed. Here, we review the advances in the development of Ad vectors suitable for stem cells and discuss their application in basic biology and clinical medicine.
引用
收藏
页码：95 / 103
页数：9
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