The highly diastereoselective synthesis of oxazolidines derived from ketones and pseudoephedrine or ephedrine

被引：7
|
作者：
Buckley, BR
Page, PCB [1 ]
Edgar, M
Elsegood, MRJ
Hayman, CM
Heaney, H
Rassias, GA
Talib, SA
Liddle, J
Readshaw, SA
Seaman, CJ
机构：
[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England
[3] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
来源：
SYNLETT | 2005年 / 06期
关键词：
amino alcohols; heterocycles; ketones; scandium; stereoselective;
D O I：
10.1055/s-2005-864824
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2,2-Dialkyl-3,4-dimethyl-5-phenyloxazolidines and 2-alkyl-2-aryl-3,4-dimethyl-5-phenyloxazolidines are formed with high diastereoselectivity from ketones and pseudoephedrine or ephedrine in the presence of scandium triflate and 4 A molecular sieves.
引用
收藏
页码：971 / 975
页数：5
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