Tight junctions in epidermis: from barrier to keratinization

被引：35

作者：

Morita, Kazumasa ^{[1
]}

Miyachi, Yoshiki ^{[2
]}

Furuse, Mikio ^{[3
]}

机构：

[1] Tenri Hosp, Dept Dermatol, Tenri, Nara 6328552, Japan

[2] Kyoto Univ, Dept Dermatol, Grad Sch Med, Kyoto 7558503, Japan

[3] Kobe Univ, Div Cell Biol, Dept Physiol & Cell Biol, Grad Sch Med, Kobe, Hyogo 6500017, Japan

来源：

EUROPEAN JOURNAL OF DERMATOLOGY | 2011年 / 21卷 / 01期

关键词：

barrier; claudin; keratinization; occludin; tight junctions; STRIA VASCULARIS; PROTEIN; OCCLUDIN; CLAUDIN; STRANDS; MICE; PHOSPHORYLATION; IDENTIFICATION; KERATINOCYTES; PARACELLIN-1;

D O I：

10.1684/ejd.2010.1192

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Tight junctions (TJs) are one type of intercellular junction. TJs prevent diffusion of solutes through the intercellular spaces in simple and stratified epithelia. Mice lacking claudin-1 (an adhesion molecule at TJs) show dehydration from the skin by impaired barrier function of epidermal TJs. Meanwhile, a human hereditary disease with ichthyosis (NISCH syndrome) has been found to be a claudin-1-deficient disease. The two models of lacking-claudin-1 indicate that TJs are related not only to the epidermal barrier but also to keratinization. Research of TJs in epidermis is reviewed in view of the barrier to keratinization.

引用

页码：12 / 17

页数：6

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