New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

被引：19
|
作者：
Centenera, Margaret M. [1 ,2 ,3 ]
Selth, Luke A. [1 ,2 ,4 ]
Ebrahimie, Esmaeil [4 ]
Butler, Lisa M. [1 ,2 ,3 ]
Tilley, Wayne D. [1 ,2 ,4 ]
机构：
[1] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia
[3] South Australian Hlth & Med Res Inst, Adelaide, SA 5001, Australia
[4] Univ Adelaide, Adelaide Med Sch, Dame Roma Mitchell Canc Res Labs, Adelaide, SA 5005, Australia
来源：
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2018年 / 8卷 / 12期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
HEAT-SHOCK-PROTEIN; RANDOMIZED PHASE-II; LIGAND-BINDING DOMAIN; N-TERMINAL DOMAIN; BF3; SITE; DNA-BINDING; GLUCOCORTICOID-RECEPTOR; STRUCTURAL BASIS; HSP90; CHAPERONE; GENE-MUTATIONS;
D O I：
10.1101/cshperspect.a030478
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.
引用
收藏
页数：19
相关论文
共 50 条
  • [41] Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer
    Kohli, Manish
    Qin, Rui
    Jimenez, Rafael
    Dehm, Scott M.
    [J]. ADVANCES IN UROLOGY, 2012, 2012
  • [42] Androgen receptor in prostate cancer
    Heinlein, CA
    Chang, CS
    [J]. ENDOCRINE REVIEWS, 2004, 25 (02) : 276 - 308
  • [43] Androgen receptor and prostate cancer
    E Richter
    S Srivastava
    A Dobi
    [J]. Prostate Cancer and Prostatic Diseases, 2007, 10 : 114 - 118
  • [44] Outsmarting androgen receptor: creative approaches for targeting aberrant androgen signaling in advanced prostate cancer
    Knudsen, Karen E.
    Kelly, William Kevin
    [J]. EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2011, 6 (03) : 483 - 493
  • [45] The androgen/androgen receptor axis in prostate cancer
    Bluemn, Eric G.
    Nelson, Peter S.
    [J]. CURRENT OPINION IN ONCOLOGY, 2012, 24 (03) : 251 - 257
  • [46] Validity and Future of Primary Androgen Deprivation Therapy in Prostate Cancer. Integration in the Era of New Agents Targeting the Androgen Receptor
    Carballido, Joaquin
    [J]. ARCHIVOS ESPANOLES DE UROLOGIA, 2023, 76 (01): : 1 - 28
  • [47] Targeting the N-Terminal Domain of the Androgen Receptor: A New Approach for the Treatment of Advanced Prostate Cancer
    Antonarakis, Emmanuel S.
    Chandhasin, Chandtip
    Osbourne, Erica
    Luo, Jun
    Sadar, Marianne D.
    Perabo, Frank
    [J]. ONCOLOGIST, 2016, 21 (12): : 1427 - 1435
  • [48] Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles
    Hoang, David T.
    Iczkowski, Kenneth A.
    Kilari, Deepak
    See, William
    Nevalainen, Marja T.
    [J]. ONCOTARGET, 2017, 8 (02) : 3724 - 3745
  • [49] Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer
    Ravindranathan, Preethi
    Lee, Tae-Kyung
    Yang, Lin
    Centenera, Margaret M.
    Butler, Lisa
    Tilley, Wayne D.
    Hsieh, Jer-Tsong
    Ahn, Jung-Mo
    Raj, Ganesh V.
    [J]. NATURE COMMUNICATIONS, 2013, 4
  • [50] Targeting prostate cancer chemoprevention via the androgen receptor in a preclinical mouse model
    Koike, Hiroyuki
    De Velasco, Marco A.
    Miyazaki, Yuka
    Asahi, Chiori
    Ushida, Hiroshi
    Shimada, Keiji
    Yoshikawa, Kazuhiro
    Nishio, Kazuto
    Konishi, Noboru
    Uemura, Hirotsugu
    [J]. CANCER RESEARCH, 2010, 70
12345