New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

被引：19
|
作者：
Centenera, Margaret M. [1 ,2 ,3 ]
Selth, Luke A. [1 ,2 ,4 ]
Ebrahimie, Esmaeil [4 ]
Butler, Lisa M. [1 ,2 ,3 ]
Tilley, Wayne D. [1 ,2 ,4 ]
机构：
[1] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia
[3] South Australian Hlth & Med Res Inst, Adelaide, SA 5001, Australia
[4] Univ Adelaide, Adelaide Med Sch, Dame Roma Mitchell Canc Res Labs, Adelaide, SA 5005, Australia
来源：
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2018年 / 8卷 / 12期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
HEAT-SHOCK-PROTEIN; RANDOMIZED PHASE-II; LIGAND-BINDING DOMAIN; N-TERMINAL DOMAIN; BF3; SITE; DNA-BINDING; GLUCOCORTICOID-RECEPTOR; STRUCTURAL BASIS; HSP90; CHAPERONE; GENE-MUTATIONS;
D O I：
10.1101/cshperspect.a030478
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.
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收藏
页数：19
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