Imperative partial nephrectomy for renal cell carcinoma: Oncological and functional results

Objectives. - To study oncological results and functional results after partial nephrectomy in imperative indication for the treatment of renal cell carcinoma. Patients and methods. - From January 1990 to December 2009, 65 partial nephrectomies in 61 patients were performed in imperative indication for renal cell carcinoma. Results. - The mean age of patients was 59.3 years. The mean follow-up was 47.4 months. The tumours were asymptomatic in 87.5%. The average tumour diameter was 4.3 cm. Twenty-nine percent of patients relapsed after a mean time of 27.4 months. The morbidity was 38.5%. Preoperative and endpoint serum creatinine and renal clearance were respectively 119 mu mol/L and 63.1 mL/min versus 137 mu mol/L and 50.9 mL/min (P=0.0003; 0.0002). Overall survival at one, three, five and ten years was 98.4%, 91.2%, 91.2% and 51.9%. Conclusion. - Partial nephrectomy in imperative indication for renal cell carcinoma has helped preserve renal function but has a significant morbidity and recurrence rate. (C) 2011 Elsevier Masson SAS. All rights reserved.