Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors

被引：31

作者：

Zbinden, KG ^{[1
]}

Obst-Sander, U ^{[1
]}

Hilpert, K ^{[1
]}

Kühne, H ^{[1
]}

Banner, DW ^{[1
]}

Böhm, HJ ^{[1
]}

Stahl, M ^{[1
]}

Ackermann, J ^{[1
]}

Alig, L ^{[1
]}

Weber, L ^{[1
]}

Wessel, HP ^{[1
]}

Riederer, MA ^{[1
]}

Tschopp, TB ^{[1
]}

Lavé, T ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, CH-4070 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 23期

关键词：

D O I：

10.1016/j.bmcl.2005.04.079

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor Vila inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5344 / 5352

页数：9

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