Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors

被引：31
|
作者：
Zbinden, KG [1 ]
Obst-Sander, U [1 ]
Hilpert, K [1 ]
Kühne, H [1 ]
Banner, DW [1 ]
Böhm, HJ [1 ]
Stahl, M [1 ]
Ackermann, J [1 ]
Alig, L [1 ]
Weber, L [1 ]
Wessel, HP [1 ]
Riederer, MA [1 ]
Tschopp, TB [1 ]
Lavé, T [1 ]
机构：
[1] F Hoffmann La Roche & Co Ltd, CH-4070 Basel, Switzerland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 23期
关键词：
D O I：
10.1016/j.bmcl.2005.04.079
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor Vila inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5344 / 5352
页数：9
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