Prognostic factors in malignant pleural mesothelioma

被引：22
|
作者：
Davidson, Ben [1 ,2 ]
机构：
[1] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Pathol, N-0310 Oslo, Norway
[2] Univ Oslo, Fac Med, Inst Clin Med, N-0316 Oslo, Norway
来源：
HUMAN PATHOLOGY | 2015年 / 46卷 / 06期
关键词：
Malignant mesothelioma; Tumor markers; Diagnosis; Prognosis; Therapeutic targets; TO-LYMPHOCYTE RATIO; SERUM MESOTHELIN; POOR-PROGNOSIS; THYMIDYLATE SYNTHASE; P16/CDKN2A DELETION; EXPRESSION PATTERNS; SOLUBLE MESOTHELIN; PREDICTS SURVIVAL; FAMILY-MEMBERS; OSTEOPONTIN;
D O I：
10.1016/j.humpath.2015.02.006
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Malignant pleural mesothelioma (MPM) is a clinically aggressive tumor originating from mesothelial cells, which line the serosal cavities. Recent years have seen extensive research aimed at identifying new therapeutic targets, predictive markers and prognostic factors in this disease. These include both serum and tissue markers, and are related to multiple cellular pathways which affect cell survival, proliferation, apoptosis, angiogenesis, interaction with the immune response and DNA repair. Several of these molecules may become relevant for pathologists as part of the effort to select patient sub-populations for targeted therapy in the future. This review summarizes current data in this area and discusses their potential clinical relevance. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：789 / 804
页数：16
相关论文
共 50 条
  • [31] Contemporary Analysis of Prognostic Factors in Patients with Unresectable Malignant Pleural Mesothelioma (MPM)
    Bille, Andrea
    Zauderer, Marjorie
    Woo, Kaitlin
    Rusch, Valerie W.
    Krug, Lee M.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) : S404 - S404
  • [32] Histologic Assessment and Prognostic Factors of Malignant Pleural Mesothelioma Treated With Extrapleural Pneumonectomy
    Arrossi, Andrea V.
    Lin, E.
    Rice, David
    Moran, Cesar A.
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2008, 130 (05) : 754 - 764
  • [33] DIAGNOSIS AND PROGNOSTIC FACTORS IN MALIGNANT PLEURAL MESOTHELIOMA - A RETROSPECTIVE ANALYSIS OF 65 PATIENTS
    TAMMILEHTO, L
    MAASILTA, P
    KOSTIAINEN, S
    APPELQVIST, P
    HOLSTI, LR
    MATTSON, K
    [J]. RESPIRATION, 1992, 59 (03) : 129 - 135
  • [34] Prognostic factors affecting survival in malignant pleural mesothelioma: analysis of 125 subjects
    Komurcuoglu, Berna
    Cirak, A. Kadri
    Kirakli, S. Cenk
    Polat, Gulru
    Yucel, Nur
    Usluer, Ozan
    Erer, Onur
    Balci, Gunseli
    Gayaf, Mine
    Guldaval, Filiz
    Aktogu, Serir
    Guclu, Salih
    Ozsoz, Ayse
    Halilcolar, Huseyin
    [J]. TUMORI, 2014, 100 (01) : 55 - 59
  • [35] Prognostic factors in elderly patients with malignant pleural mesothelioma: results of a multicenter survey
    G L Ceresoli
    F Grosso
    P A Zucali
    M Mencoboni
    G Pasello
    C Ripa
    D Degiovanni
    M Simonelli
    A Bruzzone
    C Dipietrantonj
    E Piccolini
    G D Beretta
    A G Favaretto
    L Giordano
    A Santoro
    M Botta
    [J]. British Journal of Cancer, 2014, 111 : 220 - 226
  • [36] Prognostic factors in malignant mesothelioma
    Burgers, JA
    Damhuis, RAM
    [J]. LUNG CANCER, 2004, 45 : S49 - S54
  • [37] Prognostic factors in elderly patients with malignant pleural mesothelioma: results of a multicenter survey
    Ceresoli, G. L.
    Grosso, F.
    Zucali, P. A.
    Mencoboni, M.
    Pasello, G.
    Ripa, C.
    Degiovanni, D.
    Simonelli, M.
    Bruzzone, A.
    Dipietrantonj, C.
    Piccolini, E.
    Beretta, G. D.
    Favaretto, A. G.
    Giordano, L.
    Santoro, A.
    Botta, M.
    [J]. BRITISH JOURNAL OF CANCER, 2014, 111 (02) : 220 - 226
  • [38] MALIGNANT PLEURAL MESOTHELIOMA - MULTIVARIATE-ANALYSIS OF PROGNOSTIC FACTORS ON 113 PATIENTS
    FUSCO, V
    ARDIZZONI, A
    MERLO, F
    CINQUEGRANA, A
    FARAVELLI, B
    DEPALMA, M
    CHESSA, L
    NICOLO, G
    SERRA, M
    CAPACCIO, A
    ROSSO, R
    [J]. ANTICANCER RESEARCH, 1993, 13 (03) : 683 - 690
  • [39] Prognostic factors in malignant pleural mesothelioma: A retrospective study of 60 Turkish patients
    Koyuncu, Adem
    Koksal, Deniz
    Ozmen, Ozlem
    Demirag, Funda
    Bayiz, Hulya
    Aydogdu, Koray
    Berkoglu, Mine
    [J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2015, 11 (01) : 216 - 222
  • [40] Prognostic factors for progression-free and overall survival in malignant pleural mesothelioma
    Guzman-Casta, Jordi
    Carrasco-CaraChards, Sonia
    Guzman-Huesca, Jorge
    Sanchez-Rios, Carla Paola
    Riera-Sala, Rodrigo
    Martinez-Herrera, Jose Fabian
    Pena-Mirabal, Erika Sagrario
    Bonilla-Molina, Diana
    Alatorre-Alexander, Jorge Arturo
    Martinez-Barrera, Luis Manuel
    Rodriguez-Cid, Jeronimo Rafael
    [J]. THORACIC CANCER, 2021, 12 (07) : 1014 - 1022
12345